Membrane proteins are a large group of proteins that play an essential role in the cell. This group includes receptors, ion channels, transporters, and enzymes, which account for 25% of the proteins in the human genome. ...

Motivation: Integral polytopic membrane proteins contain only two types of folds in their transmembrane domains: -helix bundles and b-barrels. The increasing number of available crystal structures of these proteins ...

Background Membrane proteins represent over 25 % of human protein genes and account for more than 60 % of drug targets due to their accessibility from the extracellular environment. The increasing number of available ...