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Browsing by Author "Paredes, Roger"

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An analysis of minor variants in HIV-1 integrase (IN) for subjects with only historic evidence of integrase inhibitor (INI) resistance enrolled in study ING112574 (VIKING-3)

Paredes, Roger; Noguera-Julian, Marc; Pou, Christian; Horton, J.; Remlinger, K.; Vavro, C. (2014)
Cicle de conferències 2014-2015. Lecture.The Microbiome in HIV Infection

Paredes, Roger; Noguera-Julian, Marc; Calle, M. Luz (17-02-2015)

HIV / AIDS infection is a major health problem with more than 30 million people affected worldwide and more than 2 million new infections each year. Fortunately, antiretroviral treatments manage to reduce mortality and ...
Determinants of virological failure and antiretroviral drug resistance in Mozambique

Rupérez, María; Pou, Christian; Maculuve, Sonia; Cedeño, Samandhy; Luis, Leopoldina; Rodríguez, Judith; Letang, Emilio; Moltó, José; Macete, Eusébio; Clotet, Bonaventura; Alonso, Pedro; Menéndez, Clara; Naniche, Denise; Paredes, Roger (Oxford University Press, 2015)

Objectives: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. Methods: This was a cross-sectional study. HIV-1-infected adults on ...
Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia

Llibre, Josep M.; Bravo, Isabel; Ornelas, Arelly; Santos, José R.; Puig, Jordi; Martín Iguacel, Raquel; Paredes, Roger; Clotet, Bonaventura (Plos One, 2015)

Background Switching subjects with persistently undetectable HIV-1 viremia under antiretroviral treatment (ART) to once-daily tenofovir/emtricitabine (or lamivudine) + nevirapine is a cost-effective and well-tolerated ...
Improved Prediction of Salvage Antiretroviral Therapy Outcomes Using Ultrasensitive HIV-1 Drug Resistance Testing

Pou, Christian; Noguera-Julian, Marc; Pérez-Alvarez, Susana; Garcia, Federico; Delgado, Rafael; Dalmau, David; Álvarez-Tejado, Miguel; González, Dimitri; Chueca, Natalia; Sayada, Chalom; Pulido, Federico; Ibáñez, Laura; Rodriguez Carbonell, Cristina; Casadellà, Maria; Santos, José R.; Ruiz, Lídia; Clotet, Bonaventura; Paredes, Roger (Oxford University Press, 2014)

Background. The clinical relevance of ultrasensitive human immunodeficiency virus type 1 (HIV-1) genotypic resistance testing in antiretroviral treatment (ART)-experienced individuals remains unknown. Methods. This was ...
Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing

Cozzi-Lepri, Alessandro; Noguera-Julian, Marc; Di Giallonardo, Francesca; Schuurman, Rob; Daümer, Rob; Aitken, Sue; Ceccherini-Silberstein, Francesca; D'Arminio Monforte, Antonella; Geretti, Anna Maria; Booth, Clare L.; Kaiser, Rolf; Michalik, Claudia; Jansen, Klaus; Masquelier, Bernard; Bellecave, Pantxika; Kouyos, Roger D.; Castro, Erika; Furrer, Hansjakob; Schultze, Anna; Günthard, Huldrych F.; Brun-Vezinet, Francoise; Paredes, Roger; Metzner, Karin (Oxford University Press, 2015)

Objectives: It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. Methods: This Europe-wide case–control study included ...
Monotherapy with boosted PIs as an ART simplification strategy in clinical practice

Santos, José R.; Llibre, Josep M.; Berrio-Galan, Daniel; Bravo, Isabel; Miranda, Cristina; Pérez-Alvarez, Susana; Pérez Alvarez, Núria; Paredes, Roger; Clotet, Bonaventura; Moltó, José (Oxford University Press, 2015)

Background: Data on the efficacy of simplifying therapy using darunavir/ritonavir and lopinavir/ritonavir monotherapy in clinical practice remain limited. Methods: A retrospective single-centre study including patients ...
Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death

Casadellà, Maria; Cozzi-Lepri, Alessandro; Phillips, Andrew; Noguera-Julian, Marc; Bickel, Markus; Sedlacek, Dalibor; Zilmer, Kai; Clotet, Bonaventura; Lundgren, Jens D.; Paredes, Roger (Plos One, 2017)

Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA ...
A Post-Partum Single-Dose TDF/FTC Tail Does Not Prevent the Selection of NNRTI Resistance in Women Receiving Pre-Partum ZDV and Intrapartum Single-Dose Nevirapine to Prevent Mother-to-Child HIV-1 Transmission

Reshmi, Samuel; Paredes, Roger; Parboosing, Raveen; Moodley, Pravi; Singh, Lavanya; Naidoo, Anneta; Gordon, M. (Wiley, 2015)

Although the rates of vertical transmission of HIV in the developing world have improved to around 3% in countries like South Africa, resistance to antiretrovirals (ARV) used in Prevention of Mother-to-Child ...
Prevalence of the K65R mutation in subtype C HIV-1-infected subjects failing TDF-containing first-line antiretroviral therapy in south africa using deep sequencing

Casadellà, Maria; Noguera-Julian, Marc; Sunpath, H.; Gordon, M.; Kuritzkes, D.R.; Marconi, V.; Paredes, Roger (2014)
Primary resistance to integrase strand-transfer inhibitors in Europe

Casadellà, Maria; Van Ham, P.M.; Noguera-Julian, Marc; Van Kessel, A.; Pou, Christian; Hofstra, L.M.; Santos, José R.; Garcia, Federico; Struck, D.; Alexiev, I.; Bakken Kran, A.M.; Hoepelman, A.I.; Kostrikis, L.G.; Somogyi, S.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paraskevis, D.; Poljak, M.; Puchhammer-Stöckl, E.; Staneková, D.; Stanojevic, M.; Van Laethem, K.; Zidovec Lepej, S.; Clotet, Bonaventura; Boucher, C.A.B.; Paredes, Roger; Wensing, A.M.J. (Oxford University Press, 2015)

Objectives: The objective of this study was to define the natural genotypic variation of the HIV-1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer inhibitor (InSTI) resistance. Methods: ...
Randomized, crossover, double-blind, placebo-controlled trial to assess the lipid lowering effect of co-formulated TDF/FTC

Santos, José R.; Saumoy, M.; Curran, Adrian; Bravo, Isabel; Navarro, Jordi; Estany, Carla; Podzamczer Palter, Daniel; Ribera, Esteban; Negredo, Eugenia; Clotet, Bonaventura; Paredes, Roger (International AIDS Society, 2014)

Abstract INTRODUCTION: Previous studies have described improvements on lipid parameters when switching from other antiretroviral drugs to tenofovir (TDF) and impairments in lipid profile when discontinuing TDF. [1-3] It ...
The Lipid-Lowering Effect of Tenofovir/ Emtricitabine: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

Santos, José R.; Saumoy, M.; Curran, Adrian; Bravo, Isabel; Llibre, Josep M.; Navarro, Jordi; Estany, Carla; Podzamczer Palter, Daniel; Ribera, Esteban; Negredo, Eugenia; Clotet, Bonaventura; Paredes, Roger (Oxford University Press, 2015)

Background. It is unknown if tenofovir disoproxil fumarate (TDF), which is often coformulated with the lipidneutral emtricitabine (FTC), has a lipid-lowering effect. Methods. We performed a randomized, crossover, ...
Virological failure to raltegravir in spain: Incidence, prevalence and clinical consequences

Santos, José R.; Blanco, José Luis; Masiá, Mar; Gutiérrez, Félix; Pérez-Elías, María Jesús; Iribarren, José Antonio; Force, Lluis; Antela, Antonio; Knobel, Hernando; Salavert, Miquel; López Bernaldo de Quirós, Juan Carlos; Pino, Maria; Paredes, Roger; Clotet, Bonaventura (Oxford University Press, 2015)

Objectives: The objective of this study was to evaluate the incidence, prevalence and clinical consequences of virological failure (VF) to raltegravir-based regimens in Spain. Methods: A multicentre, retrospective, ...
Whole-Genome Sequencing of Two Bartonella bacilliformis Strains

Guillen, Yolanda; Casadellà, Maria; García-de-la-Guarda, Ruth; Espinoza-Culupú, Abraham; Paredes, Roger; Ruiz, Joaquim; Noguera-Julian, Marc (American Society for Microbiology, 2016)

Bartonella bacilliformis is the causative agent of Carrion’s disease, a highly endemic human bartonellosis in Peru. We performed a whole-genome assembly of two B. bacilliformis strains isolated from the blood of infected ...

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