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Browsing by Author "Santos, José R."

Browsing by Author "Santos, José R."

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  • Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia
    Llibre, Josep M.; Bravo, Isabel; Ornelas, Arelly; Santos, José R.; Puig, Jordi; Martín Iguacel, Raquel; Paredes, Roger; Clotet, Bonaventura (Plos One, 2015)
    Background Switching subjects with persistently undetectable HIV-1 viremia under antiretroviral treatment (ART) to once-daily tenofovir/emtricitabine (or lamivudine) + nevirapine is a cost-effective and well-tolerated ...
  • Improved Prediction of Salvage Antiretroviral Therapy Outcomes Using Ultrasensitive HIV-1 Drug Resistance Testing
    Pou, Christian; Noguera-Julian, Marc; Pérez-Alvarez, Susana; Garcia, Federico; Delgado, Rafael; Dalmau, David; Álvarez-Tejado, Miguel; González, Dimitri; Chueca, Natalia; Sayada, Chalom; Pulido, Federico; Ibáñez, Laura; Rodriguez Carbonell, Cristina; Casadellà, Maria; Santos, José R.; Ruiz, Lídia; Clotet, Bonaventura; Paredes, Roger (Oxford University Press, 2014)
    Background. The clinical relevance of ultrasensitive human immunodeficiency virus type 1 (HIV-1) genotypic resistance testing in antiretroviral treatment (ART)-experienced individuals remains unknown. Methods. This was ...
  • Monotherapy with boosted PIs as an ART simplification strategy in clinical practice
    Santos, José R.; Llibre, Josep M.; Berrio-Galan, Daniel; Bravo, Isabel; Miranda, Cristina; Pérez-Alvarez, Susana; Pérez Alvarez, Núria; Paredes, Roger; Clotet, Bonaventura; Moltó, José (Oxford University Press, 2015)
    Background: Data on the efficacy of simplifying therapy using darunavir/ritonavir and lopinavir/ritonavir monotherapy in clinical practice remain limited. Methods: A retrospective single-centre study including patients ...
  • Primary resistance to integrase strand-transfer inhibitors in Europe
    Casadellà, Maria; Van Ham, P.M.; Noguera-Julian, Marc; Van Kessel, A.; Pou, Christian; Hofstra, L.M.; Santos, José R.; Garcia, Federico; Struck, D.; Alexiev, I.; Bakken Kran, A.M.; Hoepelman, A.I.; Kostrikis, L.G.; Somogyi, S.; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paraskevis, D.; Poljak, M.; Puchhammer-Stöckl, E.; Staneková, D.; Stanojevic, M.; Van Laethem, K.; Zidovec Lepej, S.; Clotet, Bonaventura; Boucher, C.A.B.; Paredes, Roger; Wensing, A.M.J. (Oxford University Press, 2015)
    Objectives: The objective of this study was to define the natural genotypic variation of the HIV-1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer inhibitor (InSTI) resistance. Methods: ...
  • Randomized, crossover, double-blind, placebo-controlled trial to assess the lipid lowering effect of co-formulated TDF/FTC
    Santos, José R.; Saumoy, M.; Curran, Adrian; Bravo, Isabel; Navarro, Jordi; Estany, Carla; Podzamczer Palter, Daniel; Ribera, Esteban; Negredo, Eugenia; Clotet, Bonaventura; Paredes, Roger (International AIDS Society, 2014)
    Abstract INTRODUCTION: Previous studies have described improvements on lipid parameters when switching from other antiretroviral drugs to tenofovir (TDF) and impairments in lipid profile when discontinuing TDF. [1-3] It ...
  • Reduced darunavir dose is as effective in maintaining HIV suppression as the standard dose in virologically suppressed HIV-infected patients: a randomized clinical trial
    Moltó, José; Valle, Marta; Ferrer, Elena; Domingo, Pere; Curran, Adrian; Santos, José R.; Di Yacovo, María Silvana; Miranda, Cristina; Podzamczer Palter, Daniel; Clotet, Bonaventura (Oxford University Press, 2015)
    Objectives: Maximizing ART efficiency is of growing interest. This study assessed the efficacy, safety, pharmacokinetics and economics of a darunavir dose-reduction strategy. Methods: This was a multicentre, randomized, ...
  • The Lipid-Lowering Effect of Tenofovir/ Emtricitabine: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
    Santos, José R.; Saumoy, M.; Curran, Adrian; Bravo, Isabel; Llibre, Josep M.; Navarro, Jordi; Estany, Carla; Podzamczer Palter, Daniel; Ribera, Esteban; Negredo, Eugenia; Clotet, Bonaventura; Paredes, Roger (Oxford University Press, 2015)
    Background. It is unknown if tenofovir disoproxil fumarate (TDF), which is often coformulated with the lipidneutral emtricitabine (FTC), has a lipid-lowering effect. Methods. We performed a randomized, crossover, ...
  • Virological failure to raltegravir in spain: Incidence, prevalence and clinical consequences
    Santos, José R.; Blanco, José Luis; Masiá, Mar; Gutiérrez, Félix; Pérez-Elías, María Jesús; Iribarren, José Antonio; Force, Lluis; Antela, Antonio; Knobel, Hernando; Salavert, Miquel; López Bernaldo de Quirós, Juan Carlos; Pino, Maria; Paredes, Roger; Clotet, Bonaventura (Oxford University Press, 2015)
    Objectives: The objective of this study was to evaluate the incidence, prevalence and clinical consequences of virological failure (VF) to raltegravir-based regimens in Spain. Methods: A multicentre, retrospective, ...

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