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Consulteu Recerca per matèria "VIH (Virus)"

Ara es mostren els elements 1-20 de 23

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A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Mothe, B.; Hu, Xintao; Llano, Anuska; Rosati, Margherita; Olvera, Alex; Kulkarni, Viraj; Valentin, Antonio; Alicea, Candido; Pilkington, Guy R.; Sardesai, Niranjan J.; Rocafort, Muntsa; Crespo, Manel; Carrillo, Jorge; Marco, Andrés; Mullins, James I.; Dorrell, Lucy; Hanke, Thomas; Clotet, Bonaventura; Pavlakis, George N.; Felber, Barbara; Brander, Christian (BioMed Central, 2015)

Background: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen ...
A phase I randomized therapeutic MVA-B vaccination improves the magnitude and quality of the T cell immune responses in HIV-1-infected subjects on HAART

Gómez, Carmen E.; Perdiguero, Beatriz; García Arriaza, Juan; Cepeda, Victoria; Sánchez-Sorzano, Carlos Óscar; Mothe, B.; Jiménez, José Luis; Muñoz Fernández, María Ángeles; Gatell, J.M.; López Bernaldo de Quirós, Juan Carlos; Brander, Christian; Garcia, Felipe; Esteban, Mariano (Plos One, 2015)

Trial Design Previous studies suggested that poxvirus-based vaccines might be instrumental in the therapeutic HIV field. A phase I clinical trial was conducted in HIV-1-infected patients on highly active antiretroviral ...
Antiviral activity and CSF concentrations of 600/100 mg of darunavir/ritonavir once daily in HIV-1 patients with plasma viral suppression

Di Yacovo, María Silvana; Moltó, José; Ferrer, Elena; Curran, Adrian; Else, Laura; Gisslén, Magnus; Clotet, Bonaventura; Tiraboschi, Juan M.; Niubò, Jordi; Vila, Antonia; Zetterberg, H.; Back, David; Podzamczer Palter, Daniel (Oxford University Press, 2015)

Objectives: The objective of this study was to assess whether a lower dose than the currently used one of darunavir/ ritonavir might achieve good CSF concentrations and contribute to inhibition of CNS viral replication. Patients ...
Case report: Rapid HIV progression during acute HIV-1 subtype C infection in a mozambican patient with atypical seroconversion

Velasco, Cesar; Parker, Erica; Pastor, Lucia; Nhama, Abel; Macuacua, Salesio; Mandomando, Inácio; Blanco, Julià; Naniche, Denise (American Society of Tropical Medicine and Hygiene, 2015)
Comparison of two different strategies of treatment with zoledronate in HIV-infected patients with low bone mineral density: single dose versus two doses in 2 years

Negredo, Eugenia; Bonjoch, Anna; Pérez Alvarez, Núria; Ornelas, Arelly; Puig, Jordi; Herrero, C.; Estany, Carla; Río, L. del; Gregorio, S. di; Echeverria, Patricia; Clotet, Bonaventura (Blackwell Publishing, 2015)

Objectives Given the need for easily managed treatment of osteoporosis in HIV-infected patients, we evaluated the efficacy and tolerability of two doses of zoledronate, by comparing three groups of patients: those with ...
Detection of HIV-1-specific T-cell immune responses in highly HIV-exposed uninfected individuals by in-vitro dendritic cell co-culture

Guardo, Alberto C.; Ruiz-Riol, Marta; Fernández, Emma; Maleno, Maria J.; Bargalló, Manel E.; Leon, Agathe; Climent, Núria; García, Felipe; Gatell, J.M.; Brander, Christian; Plana, Montserrat (Wolters Kluwer Health, 2015)

Background: Although virus-specific responses are rarely detected by conventional approaches, we report here the detection of T-cell responses in HIV-exposed seronegative (HESN) patients by two distinct assays. Methods: ...
Determinants of virological failure and antiretroviral drug resistance in Mozambique

Rupérez, María; Pou, Christian; Maculuve, Sonia; Cedeño, Samandhy; Luis, Leopoldina; Rodríguez, Judith; Letang, Emilio; Moltó, José; Macete, Eusébio; Clotet, Bonaventura; Alonso, Pedro; Menéndez, Clara; Naniche, Denise; Paredes, Roger (Oxford University Press, 2015)

Objectives: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. Methods: This was a cross-sectional study. HIV-1-infected adults on ...
Establishment and replenishment of the viral reservoir in perinatally HIV-1-infected children initiating very early antiretroviral therapy

Martínez-Bonet, Marta; Puertas, M.C.; Fortuny, Claudia; Ouchi, Dan; Mellado, Maria José; Rojo, Pablo; Noguera-Julian, Antoni; Muñoz Fernández, María Ángeles; Martinez Picado, Francisco Javier (Oxford University Press, 2015)

Background. Combination antiretroviral therapy (cART) generally suppresses the replication of the human immunodeficiency virus type 1 (HIV-1) but does not cure the infection, because proviruses persist in stable ...
Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals

Carrillo, Jorge; Molinos-Albert, Luis M.; Rodríguez de la Concepción, Maria L.; Marfil, Sílvia; García, Elisabet; Derking, Ronald; Sanders, Rogier W.; Clotet, Bonaventura; Blanco, Julià (Plos One, 2015)

Antibodies with the ability to block the interaction of HIV-1 envelope glycoprotein (Env) gp120 with CD4, including those overlapping the CD4 binding site (CD4bs antibodies), can protect from infection by HIV-1, and their ...
HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

Pino, Maria; Erkizia, Itziar; Benet, Susana; Erikson, Elina; Fernández Figueras, María Teresa; Guerrero, Dolores; Dalmau, Judith; Ouchi, Dan; Rausell, Antonio; Ciuffi, Angela; Keppler, Oliver T.; Telenti, Amalio; Kräusslich, H.G.; Martinez Picado, Francisco Javier; Izquierdo Useros, Nuria (BioMed Central, 2015)

Background: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, ...
Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1

Berger, Christoph T.; Llano, Anuska; Carlson, Jonathan M.; Brumme, Zabrina L.; Brockman, Mark A.; Cedeño, Samandhy; Harrigan, R.; Kaufmann, Daniel E.; Heckerman, David; Meyerhans, Andreas; Brander, Christian (American Society for Microbiology, 2015)

Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using ...
Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing

Cozzi-Lepri, Alessandro; Noguera-Julian, Marc; Di Giallonardo, Francesca; Schuurman, Rob; Daümer, Rob; Aitken, Sue; Ceccherini-Silberstein, Francesca; D'Arminio Monforte, Antonella; Geretti, Anna Maria; Booth, Clare L.; Kaiser, Rolf; Michalik, Claudia; Jansen, Klaus; Masquelier, Bernard; Bellecave, Pantxika; Kouyos, Roger D.; Castro, Erika; Furrer, Hansjakob; Schultze, Anna; Günthard, Huldrych F.; Brun-Vezinet, Francoise; Paredes, Roger; Metzner, Karin (Oxford University Press, 2015)

Objectives: It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. Methods: This Europe-wide case–control study included ...
Perfil de resistencias y barrera genética de dolutegravir

Llibre, Josep M.; Clotet, Bonaventura (Elsevier, 2015)

Dolutegravir tiene un perfil de resistencias significativamente distinto al de anteriores inhibidores de la integrasa. Es activo in vitro frente a VIH-1 (virus de la inmunodeficiencia humana-1) portador de cualquier mutación ...
Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death

Casadellà, Maria; Cozzi-Lepri, Alessandro; Phillips, Andrew; Noguera-Julian, Marc; Bickel, Markus; Sedlacek, Dalibor; Zilmer, Kai; Clotet, Bonaventura; Lundgren, Jens D.; Paredes, Roger (Plos One, 2017)

Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA ...
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

Molinos-Albert, Luis M.; Bilbao, Eneritz; Agulló, Luis; Marfil, Sílvia; García, Elisabet; Rodríguez de la Concepción, Maria L.; Izquierdo Useros, Nuria; Vilaplana, Cristina; Nieto-Garai, Jon A.; Contreras, F. Xabier; Floor, Martin; Cardona, Pere J.; Martinez Picado, Francisco Javier; Clotet, Bonaventura; Villà-Freixa, Jordi; Lorizate, M.; Carrillo, Jorge; Blanco, Julià (Nature Publishing Group, 2017)

The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by ...
Reduced darunavir dose is as effective in maintaining HIV suppression as the standard dose in virologically suppressed HIV-infected patients: a randomized clinical trial

Moltó, José; Valle, Marta; Ferrer, Elena; Domingo, Pere; Curran, Adrian; Santos, José R.; Di Yacovo, María Silvana; Miranda, Cristina; Podzamczer Palter, Daniel; Clotet, Bonaventura (Oxford University Press, 2015)

Objectives: Maximizing ART efficiency is of growing interest. This study assessed the efficacy, safety, pharmacokinetics and economics of a darunavir dose-reduction strategy. Methods: This was a multicentre, randomized, ...
Risk of HIV infection as a function of the duration of intravenous drug use: a non-parametric Bayesian approach

Gómez, Guadalupe; Calle, M. Luz; Egea, José M.; Muga, Robert (John Wiley & Sons, 2000)

We analyse the elapsed time between intravenous (IV) drug initiation and HIV infection in a cohort of 972 injecting drug users attending a hospital detoxi cation unit. We use the time of seroconversion instead of the time ...
Safety and immunogenicity of a modified vaccinia ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1

Mothe, B.; Climent, Núria; Plana, Montserrat; Rosas, Miriam; Jiménez, José Luis; Muñoz Fernández, María Ángeles; Puertas, M.C.; Carrillo, Jorge; Gonzalez, Nuria; Leon, Agathe; Pich, Judit; Arnaiz, Joan Albert; Gatell, J.M.; Clotet, Bonaventura; Blanco, Julià; Alcamí, José; Martinez Picado, Francisco Javier; Alvarez Fernández, Carmen; Sánchez Palomino, Sonsoles; Guardo, Alberto C.; Peña, José; Benito, José M.; Rallón, Norma; Gómez, Carmen E.; Perdiguero, Beatriz; García Arriaza, Juan; Esteban, Mariano; López Bernaldo de Quirós, Juan Carlos; Brander, Christian; Garcia, Felipe (Oxford University Press, 2015)

Objectives: The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing ...
Statistical methods for the analysis of microbiome compositional data in HIV studies

Rivera Pinto, Javier (30-11-2018)

El microbioma humano participa en muchas funciones esenciales como la digestión de alimentos y el mantenimiento del sistema inmunitario. Alteraciones en su composición pueden afectar a la salud del individuo, habiendo ...
Ten-year safety with polyacrylamide gel used to correct facial lipoatrophy in HIV-infected patients

Negredo, Eugenia; Puig, Jordi; Ornelas, Arelly; Echeverria, Patricia; Bonjoch, Anna; Estany, Carla; Higueras, Carmen; Gonzalez-Mestre, Vicente; Clotet, Bonaventura (Mary Ann Liebert, 2015)

Long-term results ( > 5 years) for synthetic substances used to repair facial lipoatrophy have not been published. We performed a cross-sectional study to evaluate the 10-year safety of polyacrylamide hydrogel (Aquamid) among ...

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Consulteu Recerca per matèria "VIH (Virus)"

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