Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients

Puertas, M.C.; Salgado, Maria; Morón López, Sara; Ouchi, Dan; Muñoz-Moreno, José A.; Clotet, Bonaventura; Martinez Picado, Francisco Javier

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dc.contributor	Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author	Puertas, M.C.
dc.contributor.author	Salgado, Maria
dc.contributor.author	Morón López, Sara
dc.contributor.author	Ouchi, Dan
dc.contributor.author	Muñoz-Moreno, José A.
dc.contributor.author	Clotet, Bonaventura
dc.contributor.author	Martinez Picado, Francisco Javier
dc.date.accessioned	2014-09-17T09:57:17Z
dc.date.available	2014-09-17T09:57:17Z
dc.date.created	2014
dc.date.issued	2014
dc.identifier.citation	Puertas, M. C., Salgado, M., López, S. M., Ouchi, D., Muñoz-Moreno, J. A., Moltó, J., et al. (2014). Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients. Aids, 28(14), 2157-2159. 10.1097/QAD.0000000000000373	ca_ES
dc.identifier.issn	0269-9370
dc.identifier.uri	http://hdl.handle.net/10854/3265
dc.description.abstract	Previous in-vitro data pointed out lithium, an activator of the b-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4R T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size.	en
dc.format	application/pdf
dc.format.extent	10 p.	ca_ES
dc.language.iso	eng	ca_ES
dc.publisher	Lippincott Williams & Wilkins	ca_ES
dc.rights	(c) Lippincott Williams & Wilkins
dc.rights	Tots els drets reservats	ca_ES
dc.subject.other	Sida -- Tractament	ca_ES
dc.title	Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients	en
dc.type	info:eu-repo/semantics/article	ca_ES
dc.identifier.doi	https://doi.org/10.1097/QAD.0000000000000373
dc.relation.publisherversion	http://journals.lww.com/aidsonline/Abstract/2014/09100/HIV_2_X4_tropism_is_associated_with_lower_CD4_.18.aspx
dc.rights.accessRights	info:eu-repo/semantics/closedAccess	ca_ES
dc.type.version	info:eu-repo/publishedVersion	ca_ES
dc.indexacio	Indexat a WOS/JCR
dc.indexacio	Indexat a SCOPUS	ca_ES