dc.contributor |
Universitat de Vic. Càtedra de la Sida i Malalties Relacionades |
|
dc.contributor.author |
Cozzi-Lepri, Alessandro
|
|
dc.contributor.author |
Noguera-Julian, Marc
|
|
dc.contributor.author |
Di Giallonardo, Francesca
|
|
dc.contributor.author |
Schuurman, Rob
|
|
dc.contributor.author |
Daümer, Rob
|
|
dc.contributor.author |
Aitken, Sue
|
|
dc.contributor.author |
Ceccherini-Silberstein, Francesca
|
|
dc.contributor.author |
D'Arminio Monforte, Antonella
|
|
dc.contributor.author |
Geretti, Anna Maria
|
|
dc.contributor.author |
Booth, Clare L.
|
|
dc.contributor.author |
Kaiser, Rolf
|
|
dc.contributor.author |
Michalik, Claudia
|
|
dc.contributor.author |
Jansen, Klaus
|
|
dc.contributor.author |
Masquelier, Bernard
|
|
dc.contributor.author |
Bellecave, Pantxika
|
|
dc.contributor.author |
Kouyos, Roger D.
|
|
dc.contributor.author |
Castro, Erika
|
|
dc.contributor.author |
Furrer, Hansjakob
|
|
dc.contributor.author |
Schultze, Anna
|
|
dc.contributor.author |
Günthard, Huldrych F.
|
|
dc.contributor.author |
Brun-Vezinet, Francoise
|
|
dc.contributor.author |
Paredes, Roger
|
|
dc.contributor.author |
Metzner, Karin
|
|
dc.date.accessioned |
2015-04-15T11:40:40Z |
|
dc.date.available |
2015-04-15T11:40:40Z |
|
dc.date.created |
2015 |
|
dc.date.issued |
2015 |
|
dc.identifier.citation |
Cozzi-Lepri, A., Noguera-Julian, M., Di Giallonardo, F., Schuurman, R., Daeumer, M., Aitken, S., et al. (2015). Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: A multicohort european case-control study using centralized ultrasensitive 454 pyrosequencing. Journal of Antimicrobial Chemotherapy, 70(3), 930-940. |
ca_ES |
dc.identifier.issn |
1460-2091 |
|
dc.identifier.uri |
http://hdl.handle.net/10854/3989 |
|
dc.description.abstract |
Objectives: It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological
outcomes of first-line NNRTI-containing ART.
Methods: This Europe-wide case–control study included ART-naive subjects infected with drug-susceptible HIV-1
as revealed by population sequencing, who achieved virological suppression on first-line ART including one NNRTI.
Cases experienced virological failure and controls were subjects from the same cohort whose viraemia remained
suppressed at a matched time since initiation of ART. Blinded, centralized 454 pyrosequencing with parallel
bioinformatic analysis in two laboratories was used to identify MVs in the 1%–25% frequency range. ORs of
virological failure according to MV detection were estimated by logistic regression.
Results: Two hundred and sixty samples (76 cases and 184 controls), mostly subtype B (73.5%),were used for the
analysis. Identical MVs were detected in the two laboratories. 31.6% of cases and 16.8% of controls harboured
pre-existing MVs. Detection of at least one MV versus no MVs was associated with an increased risk of virological
failure (OR¼2.75, 95% CI¼1.35–5.60, P¼0.005); similar associations were observed for at least one MV versus
no NRTIMVs (OR¼2.27, 95% CI¼0.76–6.77, P¼0.140) and at least oneMV versus no NNRTIMVs (OR¼2.41, 95%
CI¼1.12–5.18, P¼0.024). A dose–effect relationship between virological failure and mutational loadwas found.
Conclusions: Pre-existing MVs more than double the risk of virological failure to first-line NNRTI-based ART. |
ca_ES |
dc.format |
application/pdf |
|
dc.format.extent |
11 p. |
ca_ES |
dc.language.iso |
eng |
ca_ES |
dc.publisher |
Oxford University Press |
ca_ES |
dc.rights |
Tots els drets reservats |
ca_ES |
dc.rights |
(c) Oxford University Press |
|
dc.subject.other |
Sida -- Tractament |
ca_ES |
dc.subject.other |
VIH (Virus) |
ca_ES |
dc.subject.other |
Antiretrovirals |
ca_ES |
dc.title |
Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing |
ca_ES |
dc.type |
info:eu-repo/semantics/article |
ca_ES |
dc.identifier.doi |
https://doi.org/10.1093/jac/dku426 |
|
dc.relation.publisherversion |
http://jac.oxfordjournals.org/content/70/3/930.abstract |
|
dc.rights.accessRights |
info:eu-repo/semantics/closedAccess |
ca_ES |
dc.type.version |
info:eu-repo/publishedVersion |
ca_ES |
dc.indexacio |
Indexat a WOS/JCR |
ca_ES |
dc.indexacio |
Indexat a SCOPUS |
|