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Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1

Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1
 
Berger, Christoph T. ; Llano, Anuska ; Carlson, Jonathan M. ; Brumme, Zabrina L. ; Brockman, Mark A. ; Cedeño, Samandhy ; Harrigan, R. ; Kaufmann, Daniel E. ; Heckerman, David ; Meyerhans, Andreas ; Brander, Christian
2015

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Enllaç permanent: http://hdl.handle.net/10854/4320
 
Versió de l'editor: https://doi.org/10.1186/s12967-015-0392-5
 

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Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and ...»»»»
Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and characterize common CTL responses against them. Results suggest that antisense-derived sequences are commonly transcribed and translated and could encode functional proteins that contain important targets of anti-HIV cellular immunity.^^^^

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(c) American Society for Microbiology
 

Citació Bibliogràfica:

Berger, C. T., Llano, A., Carlson, J. M., Brumme, Z. L., Brockman, M. A., Cedeño, S., et al. (2015). Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1. Journal of Virology, 89(7), 4015-4019.