Methylation Data Analysis Associated with Alzheimer’s Disease

Mosquera, José Luis

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dc.contributor	Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor	Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author	Mosquera, José Luis
dc.date.accessioned	2016-03-03T10:59:04Z
dc.date.available	2016-03-03T10:59:04Z
dc.date.created	2015-09
dc.date.issued	2015-09
dc.identifier.uri	http://hdl.handle.net/10854/4445
dc.description	Curs 2014-2015	ca_ES
dc.description.abstract	Alzheimer disease (AD) is associated with distinctive changes in DNA methylation patterns. DNA methylation is a chemical modification that is involved in gene silencing. These modifications give rise to heritable changes in gene expression without altering the DNA sequence. In a first study, researchers observed differential methylated regions (DMRs) in a specific DNA in postmortem brains from AD patients. Due to this fact we decided to focus on two target genes from AD in order to compare differences in methylation between different experimental situations. In this project, we have developed a pipeline for finding DMR between different experimental conditions based on methylation data generated with the 454 GS FLX system from Roche, and DNA bisulfite-treated samples.	ca_ES
dc.format	application/pdf
dc.format.extent	62 p.	ca_ES
dc.language.iso	eng	ca_ES
dc.rights	Aquest document està subjecte a aquesta llicència Creative Commons	ca_ES
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/	ca_ES
dc.subject.other	Alzheimer, Malaltia d'	ca_ES
dc.subject.other	ADN	ca_ES
dc.title	Methylation Data Analysis Associated with Alzheimer’s Disease	ca_ES
dc.type	info:eu-repo/semantics/masterThesis	ca_ES
dc.description.version	Director/a: Malu Calle, co-director: Marta Barrachina Castillo
dc.rights.accessRights	info:eu-repo/semantics/openAccess	ca_ES