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Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Casadellà, Maria
dc.contributor.author Cozzi-Lepri, Alessandro
dc.contributor.author Phillips, Andrew
dc.contributor.author Noguera-Julian, Marc
dc.contributor.author Bickel, Markus
dc.contributor.author Sedlacek, Dalibor
dc.contributor.author Zilmer, Kai
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Lundgren, Jens D.
dc.contributor.author Paredes, Roger
dc.date.accessioned 2017-02-22T08:36:04Z
dc.date.available 2017-02-22T08:36:04Z
dc.date.created 2017
dc.date.issued 2017
dc.identifier.citation Casadellà, M., Cozzi-Lepri, A., Phillips, A., Noguera-Julian, M., Bickel, M., Sedlacek, D., et al. (2017). Plasma HIV-1 tropism and the risk of short-term clinical progression to AIDS or death. Plos One, 12(1) e0166613
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10854/4927
dc.description.abstract Objective To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design Nested case-control study within the EuroSIDA cohort. Methods Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling. Results The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2.13 vs. male, 95CI = 1.04, 4.36), p = 0.038), CD4+T-cell count (OR = 0.90 (95CI = 0.80, 1.00) per 100 cells/mm3 higher, p = 0.058), being on ART (OR = 2.72 vs. being off-ART (95CI = 1.15, 6.41), p = 0.022) and calendar year of sample [OR = 0.84 (95CI = 0.77, 0.91) per more recent year, p<0.001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups. es
dc.format application/pdf
dc.format.extent 14 p. es
dc.language.iso eng es
dc.publisher Plos One es
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons es
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ es
dc.subject.other Sida -- Tractament es
dc.subject.other VIH (Virus) es
dc.title Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death es
dc.type info:eu-repo/semantics/article es
dc.identifier.doi https://doi.org/10.1371/journal.pone.0166613
dc.rights.accesRights info:eu-repo/semantics/openAccess es
dc.type.version info:eu-repo/publishedVersion es
dc.indexacio Indexat a WOS/JCR es
dc.indexacio Indexat a SCOPUS es

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