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Phage therapy: assessment of the efficacy of a bacteriophage isolated in the treatment of salmonellosis induced by Salmonella enteritidis in mice

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dc.contributor.author Nikkhahi, Farhad
dc.contributor.author Dallal, Mohammad Mehdi Soltan
dc.contributor.author Alimohammadi, Mahmood
dc.contributor.author Foroushani, Abbas Rahimi
dc.contributor.author Rajabi, Zahra
dc.contributor.author Fardsanei, Fatemeh
dc.contributor.author Imeni, Seyed Mostafa
dc.contributor.author Bonab, Parisa Torabi
dc.date.accessioned 2017-06-20T17:04:29Z
dc.date.available 2017-06-20T17:04:29Z
dc.date.created 2017
dc.date.issued 2017
dc.identifier.citation Nikkhahi, F., Dallal, M. M. S., Alimohammadi, M., Foroushani, A. R., Rajabi, Z., Fardsanei, F., et al. (2017). Phage therapy: Assessment of the efficacy of a bacteriophage isolated in the treatment of salmonellosis induced by salmonella enteritidis in mice. Gastroenterology and Hepatology from Bed to Bench, 10(2), 131-136. es
dc.identifier.issn 2008-4234
dc.identifier.uri http://hdl.handle.net/10854/5021
dc.description.abstract Aim: This work aims to isolate and perform comparative studies of a phages active against a Salmonella enteritidis strain from Iran. Also, suitable phage candidates for therapy of mice will be selected. Background: Bacteriophage is of particular interest as a biocontrol agent in the prevention of food-borne illnesses. In recent years tend to use bacteriophages to control pathogenic bacteria has increased. A bacteriophage is considered to be a potent antibiotic alternative for treating bacterial infections. Methods: the specific phages against Salmonella Enteritidis was isolated and candidates for therapy of mice will be selected. Mouses divided into the six specific groups. Groups of mice were as follows: A: Bacteri (control) B: Bacteri+ bacteriophage (Simultaneous), C: Bacteri + bacteriophage Four days later, D: Bacteriophage + bacteri four days later E: Bacteri+ Ciprofloxacin (Simultaneous) F: Bacteri+ ciprofloxacin+ bacteriophage (Simultaneous). Results: In this study, a lytic bacteriophage is isolated and it shows that phage has a head size of 46 nm and without a tail, by using an electron microscope. Oral administration of a single dose of 2 × 109 PFU/mouse bacteriophage enable to protect mouse against salmonellosis and it causes treatment of salmonellosis in mice. Conclusion: The use of this phage compared to ciprofloxacin shows that in addition of the treatment of mouse, it also prevents weight loss. es
dc.format application/pdf
dc.format.extent 6 p. es
dc.language.iso eng es
dc.publisher Research Institute for Gastroenterology and Liver Diseases es
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons es
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ es
dc.subject.other Bacteriòfags es
dc.subject.other Salmonel·la es
dc.title Phage therapy: assessment of the efficacy of a bacteriophage isolated in the treatment of salmonellosis induced by Salmonella enteritidis in mice es
dc.type info:eu-repo/semantics/article es
dc.identifier.doi https://doi.org/10.22037/ghfbb.v0i0.1003
dc.rights.accesRights info:eu-repo/semantics/openAccess es
dc.type.version info:eu-repo/publishedVersion es
dc.indexacio Indexat a SCOPUS es

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