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Browsing by Author "Blanco, Julià"

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Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals

Molinos-Albert, Luis M.; Carrillo, Jorge; Curriu, Marta; Rodríguez de la Concepción, Maria L.; Marfil, Sílvia; García, Elisabet; Clotet, Bonaventura; Blanco, Julià (Biomed central, 2014)

Background The MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic environment seems to hamper the elicitation of ...
Case report: Rapid HIV progression during acute HIV-1 subtype C infection in a mozambican patient with atypical seroconversion

Velasco, Cesar; Parker, Erica; Pastor, Lucia; Nhama, Abel; Macuacua, Salesio; Mandomando, Inácio; Blanco, Julià; Naniche, Denise (American Society of Tropical Medicine and Hygiene, 2015)
Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals

Massanella, Marta; Ouchi, Dan; Marfil, Sílvia; Llibre, Josep M.; Puertas, M.C.; Buzon, Maria J.; Richman, Douglas D.; Orna, Elisa; Stevenson, Mario; Gatell, J.M.; Domingo, Pere; Negredo, Eugenia; Martinez Picado, Francisco Javier; Clotet, Bonaventura; Blanco, Julià (Public Library of Science, 2014)

Abstract Background HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART ...
Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals

Kawana-Tachikawa, A.; Llibre, Josep M.; Bravo, Isabel; Escrig, R.; Mothe, B.; Puig, Jordi; Puertas, M.C.; Martinez Picado, Francisco Javier; Blanco, Julià; Manzardo, C.; Miró, J.M.; Iwamoto, A.; Pozniak, A.L.; Gatell, J.M.; Clotet, Bonaventura; Brander, Christian (Public Library of Science, 2014)

Background The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Methods Subjects recently infected with HIV-1 were randomized to receive anti-retroviral ...
gp120/CD4 Blocking Antibodies Are Frequently Elicited in ART-naive Chronically HIV-1 Infected Individuals

Carrillo, Jorge; Molinos-Albert, Luis M.; Rodríguez de la Concepción, Maria L.; Marfil, Sílvia; García, Elisabet; Clotet, Bonaventura; Blanco, Julià (Mary Ann Liebert, Inc, 2014)
Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals

Carrillo, Jorge; Molinos-Albert, Luis M.; Rodríguez de la Concepción, Maria L.; Marfil, Sílvia; García, Elisabet; Derking, Ronald; Sanders, Rogier W.; Clotet, Bonaventura; Blanco, Julià (Plos One, 2015)

Antibodies with the ability to block the interaction of HIV-1 envelope glycoprotein (Env) gp120 with CD4, including those overlapping the CD4 binding site (CD4bs antibodies), can protect from infection by HIV-1, and their ...
Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

Massanella, Marta; Gómez-Mora, Elisabet; Carrillo, Jorge; Curriu, Marta; Ouchi, Dan; Puig, Jordi; Negredo, Eugenia; Cabrera, Cecilia; Clotet, Bonaventura; Blanco, Julià (Biomed central, 2015)

Abstract Background: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected ...
Optimisation of HIV-1 enveloped Virus Like Particles as a personalised vaccine platform for the delivery of cancer neoantigens

Barajas Molina, Ana (Universitat de Vic - Universitat Central de Catalunya, 11-10-2023)

Cancer immunotherapies (CIT) stand as novel and promising strategies for the treatment of cancer. Their aim is to enhance the individual’s own immune system to recognise and eliminate cancer cells reducing side effects, ...
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

Molinos-Albert, Luis M.; Bilbao, Eneritz; Agulló, Luis; Marfil, Sílvia; García, Elisabet; Rodríguez de la Concepción, Maria L.; Izquierdo Useros, Nuria; Vilaplana, Cristina; Nieto-Garai, Jon A.; Contreras, F. Xabier; Floor, Martin; Cardona, Pere J.; Martinez Picado, Francisco Javier; Clotet, Bonaventura; Villà-Freixa, Jordi; Lorizate, M.; Carrillo, Jorge; Blanco, Julià (Nature Publishing Group, 2017)

The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by ...
Safety and immunogenicity of a modified vaccinia ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1

Mothe, B.; Climent, Núria; Plana, Montserrat; Rosas, Miriam; Jiménez, José Luis; Muñoz Fernández, María Ángeles; Puertas, M.C.; Carrillo, Jorge; Gonzalez, Nuria; Leon, Agathe; Pich, Judit; Arnaiz, Joan Albert; Gatell, J.M.; Clotet, Bonaventura; Blanco, Julià; Alcamí, José; Martinez Picado, Francisco Javier; Alvarez Fernández, Carmen; Sánchez Palomino, Sonsoles; Guardo, Alberto C.; Peña, José; Benito, José M.; Rallón, Norma; Gómez, Carmen E.; Perdiguero, Beatriz; García Arriaza, Juan; Esteban, Mariano; López Bernaldo de Quirós, Juan Carlos; Brander, Christian; Garcia, Felipe (Oxford University Press, 2015)

Objectives: The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing ...

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