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Consulteu per autor "Gatell, J.M."

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A phase I randomized therapeutic MVA-B vaccination improves the magnitude and quality of the T cell immune responses in HIV-1-infected subjects on HAART

Gómez, Carmen E.; Perdiguero, Beatriz; García Arriaza, Juan; Cepeda, Victoria; Sánchez-Sorzano, Carlos Óscar; Mothe, B.; Jiménez, José Luis; Muñoz Fernández, María Ángeles; Gatell, J.M.; López Bernaldo de Quirós, Juan Carlos; Brander, Christian; Garcia, Felipe; Esteban, Mariano (Plos One, 2015)

Trial Design Previous studies suggested that poxvirus-based vaccines might be instrumental in the therapeutic HIV field. A phase I clinical trial was conducted in HIV-1-infected patients on highly active antiretroviral ...
Detection of HIV-1-specific T-cell immune responses in highly HIV-exposed uninfected individuals by in-vitro dendritic cell co-culture

Guardo, Alberto C.; Ruiz-Riol, Marta; Fernández, Emma; Maleno, Maria J.; Bargalló, Manel E.; Leon, Agathe; Climent, Núria; García, Felipe; Gatell, J.M.; Brander, Christian; Plana, Montserrat (Wolters Kluwer Health, 2015)

Background: Although virus-specific responses are rarely detected by conventional approaches, we report here the detection of T-cell responses in HIV-exposed seronegative (HESN) patients by two distinct assays. Methods: ...
Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals

Massanella, Marta; Ouchi, Dan; Marfil, Sílvia; Llibre, Josep M.; Puertas, M.C.; Buzon, Maria J.; Richman, Douglas D.; Orna, Elisa; Stevenson, Mario; Gatell, J.M.; Domingo, Pere; Negredo, Eugenia; Martinez Picado, Francisco Javier; Clotet, Bonaventura; Blanco, Julià (Public Library of Science, 2014)

Abstract Background HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART ...
Effect of Maraviroc Intensification on HIV-1-Specific T Cell Immunity in Recently HIV-1-Infected Individuals

Kawana-Tachikawa, A.; Llibre, Josep M.; Bravo, Isabel; Escrig, R.; Mothe, B.; Puig, Jordi; Puertas, M.C.; Martinez Picado, Francisco Javier; Blanco, Julià; Manzardo, C.; Miró, J.M.; Iwamoto, A.; Pozniak, A.L.; Gatell, J.M.; Clotet, Bonaventura; Brander, Christian (Public Library of Science, 2014)

Background The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Methods Subjects recently infected with HIV-1 were randomized to receive anti-retroviral ...
MicroRNA Profile in CD8+ T-Lymphocytes from HIV-Infected Individuals: Relationship with Antiviral Immune Response and Disease Progression

Egaña-Gorroño, Lander; Guardo, Alberto C.; Bargalló, Manel E.; Planet, Evarist; Vilaplana, Elisenda; Escribà, Tuixent; Pérez, Iñaki; Gatell, J.M.; Garcia, Felipe; Arnedo, Mireia; Plana, Montserrat (Public Library of Science, 2016)

Background The relationship between host microRNAs (miRNA), viral control and immune response has not yet been elucidated in the field of HIV. The aim of this study was to assess the differential miRNA profile in CD8+ ...
Safety and immunogenicity of a modified vaccinia ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1

Mothe, B.; Climent, Núria; Plana, Montserrat; Rosas, Miriam; Jiménez, José Luis; Muñoz Fernández, María Ángeles; Puertas, M.C.; Carrillo, Jorge; Gonzalez, Nuria; Leon, Agathe; Pich, Judit; Arnaiz, Joan Albert; Gatell, J.M.; Clotet, Bonaventura; Blanco, Julià; Alcamí, José; Martinez Picado, Francisco Javier; Alvarez Fernández, Carmen; Sánchez Palomino, Sonsoles; Guardo, Alberto C.; Peña, José; Benito, José M.; Rallón, Norma; Gómez, Carmen E.; Perdiguero, Beatriz; García Arriaza, Juan; Esteban, Mariano; López Bernaldo de Quirós, Juan Carlos; Brander, Christian; Garcia, Felipe (Oxford University Press, 2015)

Objectives: The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing ...

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Consulteu per autor "Gatell, J.M."

Consulteu per autor "Gatell, J.M."

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