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Browsing by Author "Malats i Riera, Núria"

Browsing by Author "Malats i Riera, Núria"

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  • A dynamic model for the risk of bladder cancer progression
    Porta, Núria; Calle, M. Luz; Malats i Riera, Núria; Gómez, Guadalupe (Wiley, 2012)
    We propose a multistate modeling approach to describe the observed evolution of patients diagnosed with nonmuscle- invasive bladder cancer. On the basis of data from the Spanish Bladder Cancer/EPICURO study, we adjust a ...
  • Application of Multi-SNP Approaches Bayesian LASSO and AUC-RF to Detect Main Effects of Inflammatory-Gene Variants Associated with Bladder Cancer Risk
    López de Maturana, Evangelina; Ye, Yuanging; Calle, M. Luz; Rothman, Nathaniel; Urrea Gales, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen; Tardón, Adonina; García-Closas, Montserrat; González-Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro, Arcadi; Lorente-Galdós, Belén; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science, 2013)
    The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
  • AUC-RF: A New Strategy for Genomic Profiling with Random Forest
    Calle, M. Luz; Urrea Gales, Víctor; Boulesteix, Anne-Laure; Malats i Riera, Núria (Karger, 2011)
    Objective: Genomic profiling, the use of genetic variants at multiple loci simultaneously for the prediction of disease risk, requires the selection of a set of genetic variants that best predicts disease status. The ...
  • Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes
    Guey, Lin T.; García-Closas, Montserrat; Murta-Nascimento, Cristiane; Lloreta, Josep; Palencia, Laia; Kogevinas, Manolis; Rothman, Nathaniel; Vellalta, Gemma; Calle, M. Luz; Marenne, Gaëlle; Tardón, Adonina; Carrato, Alfredo; García Closas, Reina; Serra, Consol; Silverman, Debra T.; Chanock, Stephen; Real, Francisco X.; Malats i Riera, Núria (Elsevier, 2010)
    Background: Clinical, pathologic, and molecular evidence indicate that bladder cancer is heterogeneous with pathologic/molecular features that define distinct subphenotypes with different prognoses. It is conceivable ...
  • Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. A Comprehensive Analysis
    Pineda, S.; Milne, R.L.; Calle, M. Luz; Rothman, Nathaniel; López de Maturana, Evangelina; Herranz, J.; Kogevinas, Manolis; Chanock, Stephen; Tardón, Adonina; Márquez, M.; Guey, Lin T.; García-Closas, Montserrat; Lloreta, Josep; Baum, E.; González-Neira, Anna; Carrato, Alfredo; Navarro, Arcadi; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science, 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in ...
  • Improving strategies for detecting genetic patterns of disease susceptibility in association studies
    Calle, M. Luz; Urrea Gales, Víctor; Vellalta, Gemma; Malats i Riera, Núria; Steen, K.V. (Wiley InterScience, 2008)
    The analysis of gene interactions and epistatic patterns of susceptibility is especially important for investigating complex diseases such as cancer characterized by the joint action of several genes. This work is motivated ...
  • MB-MDR: Model-Based Multifactor Dimensionality Reduction for detecting interactions in high-dimensional genomic data
    Calle, M. Luz; Urrea Gales, Víctor; Malats i Riera, Núria; Van Steen, Kristel (05-02-2008)
    L’anàlisi de l’efecte dels gens i els factors ambientals en el desenvolupament de malalties complexes és un gran repte estadístic i computacional. Entre les diverses metodologies de mineria de dades que s’han proposat per ...
  • mbmdr: an R package for exploring gene–gene interactions associated with binary or quantitative traits
    Calle, M. Luz; Urrea Gales, Víctor; Malats i Riera, Núria; Van Steen, Kristel (Oxford University Press, 2010)
    Summary: We describe mbmdr, an R package for implementing the model-based multifactor dimensionality reduction (MB-MDR) method. MB-MDR has been proposed by Calle et al. as a dimension reduction method for exploring ...
  • Risk Prediction Scores for Recurrence and Progression of Non-Muscle Invasive Bladder Cancer: An International Validation in Primary Tumours
    Vedder, M.M.; Márquez, M.; Bekker-Grob de, E.W.; Calle, M. Luz; Dyrskjot, L.; Kogevinas, Manolis; Segersten, U.; Malmström, P.U.; Algaba, F.; Beukers, W.; Orntoft, T.F.; Zwarthoff, E.; Real, Francisco X.; Malats i Riera, Núria; Steyerberg, E.W. (Plos One, 2014)
    Abstract Objective: We aimed to determine the validity of two risk scores for patients with non-muscle invasive bladder cancer in different European settings, in patients with primary tumours. Methods: We included 1,892 ...
  • Selenoproteins and bladder cancer risk: A case-control study
    Amaral, A.F.S.; Rothman, Nathaniel; Kogevinas, Manolis; Calle, M. Luz; Guey, Lin T.; García-Closas, Montserrat; Silverman, Debra T.; Chanock, Stephen; Real, Francisco X.; Malats i Riera, Núria (Elsevier, 2010)
  • Whole Genome Prediction of Bladder Cancer Risk With the Bayesian LASSO
    López de Maturana, Evangelina; Chanock, Stephen; Picornell, A.C.; Rothman, Nathaniel; Herranz, J.; Calle, M. Luz; García-Closas, Montserrat; Marenne, Gaëlle; Brand, A.; Tardón, Adonina; Carrato, Alfredo; Silverman, Debra T.; Kogevinas, Manolis; Gianola, D.; Real, Francisco X.; Malats i Riera, Núria (Wiley, 2014)
    To build a predictive model for urothelial carcinoma of the bladder (UCB) risk combining both genomic and nongenomic data, 1,127 cases and 1,090 controls from the Spanish Bladder Cancer/EPICURO study were genotyped using ...