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Integrative analysis of the Regulatory Region of the FGFR3 Oncogene

Integrative analysis of the Regulatory Region of the FGFR3 Oncogene
 
Bau i Macià, Josep ; Cullell i Dalmau, Marta ; Solé-Casals, Jordi
2011

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Enllaç permanent: http://hdl.handle.net/10854/2076
 
Versió de l'editor: https://doi.org/10.1007/978-3-642-19914-1
 

Abstract

The study of transcriptional regulation often needs the integration of diverse yet independent data. In the present work, sequence conservation, predic-tion of transcription factor binding sites (TFBS) and gene expression analysis have been applied to the detection of putative transcription factor (TF) modules in the regulatory ...»»»»
The study of transcriptional regulation often needs the integration of diverse yet independent data. In the present work, sequence conservation, predic-tion of transcription factor binding sites (TFBS) and gene expression analysis have been applied to the detection of putative transcription factor (TF) modules in the regulatory region of the FGFR3 oncogene. Several TFs with conserved binding sites in the FGFR3 regulatory region have shown high positive or negative corre-lation with FGFR3 expression both in urothelial carcinoma and in benign nevi. By means of conserved TF cluster analysis, two different TF modules have been iden-tified in the promoter and first intron of FGFR3 gene. These modules contain acti-vating AP2, E2F, E47 and SP1 binding sites plus motifs for EGR with possible repressor function.^^^^

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Conference object

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(c) Springer, 2011
 
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Citation:

BAU MACIÀ, Josep; CULLELL, Marta; SOLÉ CASALS, Jordi. "Integrative Analysis of the Regulatory Region of the FGFR3 Oncogene". A: 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (Pacbb 2011), 2011, vol. 93, pàg. 201-204.