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Chromatin-Bound IkBa Regulates a Subset of Polycomb Target Genes in Differentiation and Cancer

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dc.contributor Universitat de Vic. Escola Politècnica Superior
dc.contributor Universitat de Vic. Grup de Recerca en Bioinformàtica i Estadística Mèdica
dc.contributor.author Mulero, María Carmen
dc.contributor.author Ferres-Marco, Dolors
dc.contributor.author Islam, Abul
dc.contributor.author Margalef, Pol
dc.contributor.author Pecoraro, Matteo
dc.contributor.author Toll, Agustí
dc.contributor.author Drechsel, Nils
dc.contributor.author Charneco, Cristina
dc.contributor.author Davies, Shelly
dc.contributor.author Bellora, Nicolás
dc.contributor.author Gallardo, Fernando
dc.contributor.author López-Arribillaga, Erika
dc.contributor.author Asensio-Juan, Elena
dc.contributor.author Rodilla, Verónica
dc.contributor.author González, Jessica
dc.contributor.author Iglesias, Mar
dc.contributor.author Shih, Vincent
dc.contributor.author Albà, M. Mar
dc.contributor.author Di Croce, Luciano
dc.contributor.author Hoffmann, Alexander
dc.contributor.author Miyamoto, Shigeki
dc.contributor.author Villà-Freixa, Jordi
dc.contributor.author López Bigas, Núria
dc.contributor.author Keyes, William M.
dc.contributor.author Domínguez, María
dc.contributor.author Bigas, Anna
dc.contributor.author Espinosa, Lluís
dc.date.accessioned 2013-10-28T10:38:15Z
dc.date.available 2013-10-28T10:38:15Z
dc.date.issued 2013
dc.identifier.citation Mulero et al., Chromatin-Bound IkBa Regulates a Subset of Polycomb Target Genes in Differentiation and Cancer, Cancer Cell (2013), http://dx.doi.org/10.1016/j.ccr.2013.06.003 ca_ES
dc.identifier.issn 1535-6108
dc.identifier.uri http://hdl.handle.net/10854/2407
dc.description.abstract IkB proteins are the primary inhibitors of NF-kB. Here, we demonstrate that sumoylated and phosphorylated IkBa accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IkBa modulates Polycomb recruitment and imparts their competence to be activated by TNFa. Mutations in the Drosophila IkBa gene cactus enhance the homeotic phenotype of Polycomb mutants, which is not counteracted by mutations in dorsal/NF-kB. Oncogenic transformation of keratinocytes results in cytoplasmic IkBa translocation associated with a massive activation of Hox. Accumulation of cytoplasmic IkBa was found in squamous cell carcinoma (SCC) associated with IKK activation and HOX upregulation. ca_ES
dc.format application/pdf
dc.format.extent 16 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Elsevier ca_ES
dc.rights (c) 2013 Elsevier. Published article is available at: http://dx.doi.org/10.1016/j.ccr.2013.06.003
dc.rights Tots els drets reservats ca_ES
dc.subject.other Càncer ca_ES
dc.subject.other Genètica humana ca_ES
dc.title Chromatin-Bound IkBa Regulates a Subset of Polycomb Target Genes in Differentiation and Cancer ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1016/j.ccr.2013.06.003
dc.relation.publisherversion http://dx.doi.org/10.1016/j.ccr.2013.06.003
dc.rights.accesRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a SCOPUS
dc.indexacio Indexat a WOS/JCR ca_ES

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