• Cell compartment isoform expression analysis using long-read transcriptomics

  Carbonell-Sala, Sílvia (01-09-2023)

  Motivation: Alternative splicing, a crucial post-transcriptional process, enhances proteomic diversity without increasing gene numbers, playing pivotal roles in gene regulation, specialization, and disease. Short-read ...
• Host epigenetic changes to Salmonella Paratyphi exposure

  Pischedda, Sara (10-09-2023)

  Motivation: Typhoid fever, resulting from Salmonella enterica serovars Typhi and Paratyphi A, stands as a significant contributor to illness and mortality. Recent challenge studies on the host immunity to these Salmonella ...
• Unveiling distinct features of long-term benefit in metastatic NSCLC patients undergoing immune checkpoint blockade

  Simões Da Rocha, Pedro Filipe (01-09-2023)

  Introduction: Immunotherapy is firmly established as a treatment regimen in various solid tumors, driven by its exceptional benefits observed in a select group of patients. Despite widespread use of immune checkpoint ...
• Transcriptomic analysis of BRCA1 and BRCA2 carriers

  Vilardell Lladó, Marina (01-09-2023)

  Most frequently mutations that lead to the development of breast and ovarian cancer are BRCA1 and BRCA2. Blood samples from BRCA1, BRCA2 and non-mutation carriers were extracted for both healthy and cancer-affected ...
• Lipid metabolism as a therapeutic vulnerability in medulloblastoma

  Escudero Monreal, Laura (01-09-2023)

  Medulloblastoma (MB) is the most common malignant brain tumor in children and presents a varied prognosis, with some patients succumbing to the disease and survivors presenting neurotoxic sequelae from treatment. ...

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