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dc.contributor |
Universitat de Vic. Escola Politècnica Superior |
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dc.contributor |
Universitat de Vic. Màster Universitari en Anàlisi de Dades Òmiques |
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dc.contributor.author |
Crespi i Boixader, Alba |
|
dc.date.accessioned |
2014-03-18T13:34:33Z |
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dc.date.available |
2014-03-18T13:34:33Z |
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dc.date.created |
2014-01-20 |
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dc.date.issued |
2014-01 |
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dc.identifier.uri |
http://hdl.handle.net/10854/2777 |
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dc.description |
Curs 2012-2013 |
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dc.description.abstract |
Membrane proteins account for about 20% to 30% of all proteins encoded in a typical
genome. They play central roles in multiple cellular processes mediating the interaction of the
cell with its surrounding. Over 60% of all drug targets contain a membrane domain. The
experimental difficulties of obtaining a crystal structural severely limits our ability or
understanding of membrane protein function. Computational evolutionary studies of proteins
are crucial for the prediction of 3D structures. In this project, we construct a tool able to
quantify the evolutionary positive selective pressure on each residue of membrane proteins
through maximum likelihood phylogeny reconstruction. The conservation plot combined with
a structural homology model is also a potent tool to predict those residues that have essentials
roles in the structure and function of a membrane protein and can be very useful in the design
of validation experiments. |
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dc.format |
application/pdf |
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dc.format.extent |
21 p. |
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dc.language.iso |
eng |
ca_ES |
dc.rights |
Aquest document està subjecte a aquesta llicència Creative Commons |
ca_ES |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
ca_ES |
dc.subject.other |
Proteïnes de membrana |
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dc.subject.other |
Genomes |
ca_ES |
dc.subject.other |
Interacció cel·lular |
ca_ES |
dc.title |
Computational toolbox towards evolutionary domain mapping of membrane proteins |
ca_ES |
dc.type |
info:eu-repo/semantics/masterThesis |
ca_ES |
dc.description.version |
Director/a: Mireia Olivella i Alex Peràlvarez |
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dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
ca_ES |
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