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Computational toolbox towards evolutionary domain mapping of membrane proteins

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dc.contributor Universitat de Vic. Escola Politècnica Superior
dc.contributor Universitat de Vic. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author Crespi i Boixader, Alba
dc.date.accessioned 2014-03-18T13:34:33Z
dc.date.available 2014-03-18T13:34:33Z
dc.date.created 2014-01-20
dc.date.issued 2014-01
dc.identifier.uri http://hdl.handle.net/10854/2777
dc.description Curs 2012-2013
dc.description.abstract Membrane proteins account for about 20% to 30% of all proteins encoded in a typical genome. They play central roles in multiple cellular processes mediating the interaction of the cell with its surrounding. Over 60% of all drug targets contain a membrane domain. The experimental difficulties of obtaining a crystal structural severely limits our ability or understanding of membrane protein function. Computational evolutionary studies of proteins are crucial for the prediction of 3D structures. In this project, we construct a tool able to quantify the evolutionary positive selective pressure on each residue of membrane proteins through maximum likelihood phylogeny reconstruction. The conservation plot combined with a structural homology model is also a potent tool to predict those residues that have essentials roles in the structure and function of a membrane protein and can be very useful in the design of validation experiments. ca_ES
dc.format application/pdf
dc.format.extent 21 p. ca_ES
dc.language.iso eng ca_ES
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons ca_ES
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ca_ES
dc.subject.other Proteïnes de membrana ca_ES
dc.subject.other Genomes ca_ES
dc.subject.other Interacció cel·lular ca_ES
dc.title Computational toolbox towards evolutionary domain mapping of membrane proteins ca_ES
dc.type info:eu-repo/semantics/masterThesis ca_ES
dc.description.version Director/a: Mireia Olivella i Alex Peràlvarez
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES

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