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Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients

Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients
 
Puertas, M.C. ; Salgado, Maria ; Morón López, Sara ; Ouchi, Dan ; Muñoz-Moreno, José A. ; Clotet, Bonaventura ; Martinez Picado, Francisco Javier
2014

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Enllaç permanent: http://hdl.handle.net/10854/3265
 
Versió de l'editor: https://doi.org/10.1097/QAD.0000000000000373
 

Abstract

Previous in-vitro data pointed out lithium, an activator of the b-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate ...»»»»
Previous in-vitro data pointed out lithium, an activator of the b-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4R T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size.^^^^

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(c) Lippincott Williams & Wilkins
 
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Citation:

Puertas, M. C., Salgado, M., López, S. M., Ouchi, D., Muñoz-Moreno, J. A., Moltó, J., et al. (2014). Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients. Aids, 28(14), 2157-2159. 10.1097/QAD.0000000000000373