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The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Olvera, Alex
dc.contributor.author Pérez-Alvarez, Susana
dc.contributor.author Ibarrondo, Javier
dc.contributor.author Ganoza, C.
dc.contributor.author Lama, Javier R.
dc.contributor.author Lucchetti, Aldo
dc.contributor.author Cate, Steven
dc.contributor.author Hildebrand, William
dc.contributor.author Bernard, Nicole
dc.contributor.author Gómez, Guadalupe
dc.contributor.author Sanchez, Jorge
dc.contributor.author Brander, Christian
dc.date.accessioned 2015-04-16T09:38:01Z
dc.date.available 2015-04-16T09:38:01Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Olvera, A., Perez-Alvarez, S., Lbarrondo, J., Ganoza, C., Lama, J. R., Lucchetti, A., et al. (2015). The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. Aids, 29(5), 507-517. ca_ES
dc.identifier.issn 0269-9370
dc.identifier.uri http://hdl.handle.net/10854/3991
dc.description.abstract Objective: The objective of this study is to identify human leukocyte antigen (HLA) class I and killer-cell immunoglobulin-like receptor (KIR) genotypes associated with different risks for HIV acquisition and HIV disease progression. Design: A cross-sectional study of a cohort of 468 high-risk individuals (246 HIVpositive and 222 HIV-negative) from outpatient clinics in Lima (Peru´ ). Methods: The cohort was high-resolution HLA and KIR-typed and analysed for potential differences in single-allele frequencies and allele combinations between HIVpositive and HIV-negative individuals and for associations with HIV viral load and CD4þ cell counts in infected individuals. Results: HLA class I alleles associated with a lack of viral control had a significantly higher population frequency than relatively protective alleles (P¼0.0093), in line with a rare allele advantage. HLA-A 02 : 01 and HLA-C 04 : 01 were both associated with high viral loads (P¼0.0313 and 0.0001, respectively) and low CD4þ cell counts (P¼0.0008 and 0.0087, respectively). Importantly, the association between HLAC 04 : 01 and poor viral control was not due to its linkage disequilibrium with other HLA alleles. Rather, the coexpression of its putative KIR ligand KIR2DS4f was critically linked to elevated viral loads. Conclusion: These results highlight the impact of population allele frequency on viral control and identify a novel association between HLA-C 04 : 01 in combination with KIR2DS4f and uncontrolled HIV infection. Our data further support the importance of the interplay of markers of the adaptive and innate immune system in viral control. ca_ES
dc.format application/pdf
dc.format.extent 11 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Wolters Kluwer Health ca_ES
dc.rights Tots els drets reservats ca_ES
dc.rights (c) Wolters Kluwer Health, 2015
dc.subject.other VIH (Virus) ca_ES
dc.subject.other Antígens HLA ca_ES
dc.subject.other Sida -- Tractament
dc.title The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1097/QAD.0000000000000574
dc.rights.accessRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a WOS/JCR ca_ES
dc.indexacio Indexat a SCOPUS

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