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Cicle de conferències 2014-2015. Lecture. How to discover protein post-translational modifications… just by chance

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dc.contributor Universitat de Vic. Escola Politècnica Superior
dc.contributor.author Beltran Alvarez, Pedro
dc.date.accessioned 2015-04-27T09:42:43Z
dc.date.available 2015-04-27T09:42:43Z
dc.date.created 2015-04-28
dc.date.issued 2015-04-28
dc.identifier.uri http://hdl.handle.net/10854/4019
dc.description.abstract The voltage-gated ion channel superfamily consists of 143 proteins and includes the cardiac voltage-gated sodium channel, NaV1.5, which is essential for cardiac excitability. We have uncovered two new modifications of the voltage-gated ion channel superfamily: arginine methylation and N-terminal acetylation. By chance, we found that R513, R526 and R680 in NaV1.5 are post-translationally methylated. Then, we decided to study this new modification and identified the enzymes responsible for NaV1.5 arginine methylation (PRMT3 and PRMT5). Also, we found that arginine methylation increases NaV1.5 membrane expression. Furthermore, we observed cross-talk between NaV1.5 arginine methylation and phosphorylation of adjacent serine residues. The physiological relevance of NaV1.5 arginine methylation is underscored by the fact that R513H, R526H and R680H are known NaV1.5 mutations causing sudden cardiac death. Looking for NaV1.5 arginine methylation in human samples of heart failure, we have recently discovered that it is also acetylated at the N-terminus. We are currently investigating the clinical implications of these two novel modifications, with the ultimate goal of describing NaV1.5 arginine methylation and N-terminal acetylation as drivers or markers, and possible pharmacological targets, of cardiac disease. ca_ES
dc.format application/pdf
dc.format.extent 1 p. ca_ES
dc.language.iso eng ca_ES
dc.rights Tots els drets reservats ca_ES
dc.subject.other Biotecnologia -- Congressos ca_ES
dc.title Cicle de conferències 2014-2015. Lecture. How to discover protein post-translational modifications… just by chance ca_ES
dc.type info:eu-repo/semantics/other ca_ES
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES

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