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Combined biostatistics and bioinformatics analyses to identify epigenetically regulated host factors associated with control of HIV disease progression

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor.author Ordeig Gaja, Laura
dc.date.accessioned 2015-10-06T07:43:38Z
dc.date.available 2015-10-06T07:43:38Z
dc.date.created 2015-09
dc.date.issued 2015-09
dc.identifier.uri http://hdl.handle.net/10854/4274
dc.description Curs 2014-2015 ca_ES
dc.description.abstract A small, but considerable proportion (1-3%) of HIV infected individuals can control their infection in the absence of antiretroviral treatment (ART), while others progress to Acquired Immune-Deficiency Syndrome (AIDS) within one or few years after infection. In this work we perform a comprehensive epigenomic study of host DNA methylation in HIV infected patients using innovative methods for omics data analysis. To do this we apply a multivariate analysis, using the R-Package “CMA” from Bioconductor. 2862 Differentially Methylated Positions (DMP) related to genes were found and the multivariate analysis identified 20 of them in 16 different genes, that could be good markers to predict the control status of the infection. From these genes, including CMPK2, CXCR5, IL7R, IL6R, PARP9 and TGFBR2, a biological and functional analysis was performed using Ingenuity Pathway Analysis Software (IPA). The application of DNA methylome to HIV infection have yielded extensive new data that identify epigenetic dysregulation of Signaling and Death Receptors as new potential deregulated pathways associated with HIV control/non-control. The data thus afford a better understanding of immune-regulatory alterations and highlight the need that future therapeutic intervention strategies may have to integrate more than single target molecules. ca_ES
dc.format application/pdf
dc.format.extent 42 p. ca_ES
dc.language.iso eng ca_ES
dc.rights Tots els drets reservats ca_ES
dc.subject.other VIH (Virus) ca_ES
dc.subject.other Gens de resposta immunitària ca_ES
dc.subject.other ADN ca_ES
dc.title Combined biostatistics and bioinformatics analyses to identify epigenetically regulated host factors associated with control of HIV disease progression ca_ES
dc.type info:eu-repo/semantics/bachelorThesis ca_ES
dc.rights.accesRights info:eu-repo/semantics/closedAccess ca_ES

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