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Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Sironi, Manuela
dc.contributor.author Biasin, Mara
dc.contributor.author Pontremoli, Chiara
dc.contributor.author Cagliani, Rachele
dc.contributor.author Saulle, Irma
dc.contributor.author Trabattoni, Daria
dc.contributor.author Vichi, Francesca
dc.contributor.author Lo Caputo, Sergio
dc.contributor.author Mazzotta, Francesco
dc.contributor.author Aguilar‑Jimenez, Wbeimar
dc.contributor.author Rugeles, Maria Teresa
dc.contributor.author Cedeño, Samandhy
dc.contributor.author Sánchez, Jorge
dc.contributor.author Brander, Christian
dc.contributor.author Clerici, Mario
dc.date.accessioned 2015-11-13T10:54:33Z
dc.date.available 2015-11-13T10:54:33Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Sironi, M., Biasin, M., Pontremoli, C., Cagliani, R., Saulle, I., Trabattoni, D., et al. (2015). Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection. Retrovirology, 12, 80. ca_ES
dc.identifier.issn 1742-4690
dc.identifier.uri http://hdl.handle.net/10854/4351
dc.description.abstract Background: The genetic bases of natural resistance to HIV-1 infection remain largely unknown. Recently, two genome-wide association studies suggested a role for variants within or in the vicinity of the CYP7B1 gene in modulating HIV susceptibility. CYP7B1 is an appealing candidate for this due to its contribution to antiviral immune responses. We analyzed the frequency of two previously described CYP7B1 variants (rs6996198 and rs10808739) in three independent cohorts of HIV-1 infected subjects and HIV-1 exposed seronegative individuals (HESN). Findings: rs6996198 and rs10808739 were genotyped in three case/control cohorts of sexually-exposed HESN and HIV-1-infected individuals from Italy, Peru and Colombia. Comparison of the allele and genotype frequencies of the two SNPs under different models showed that the only significant difference was seen for rs6996198 in the Peruvian sample (nominal p = 0.048, dominant model). For this variant, a random-effect meta-analysis yielded non-significant results (dominant model, p = 0.78) and revealed substantial heterogeneity among cohorts. No significant effect of the rs10808739 allelic status on HIV-1 infection susceptibility (additive model, p = 0.30) emerged from the meta-analysis. Conclusions: Although our study had limited power to detect association due to the small sample size, comparisons among the three cohorts revealed very similar allelic and genotypic frequencies in HESN and HIV-1 positive subjects. Overall, these data indicate that the two GWAS-defined variants in the CYP7B1 region do not strongly influence HIV-1 infection susceptibility. ca_ES
dc.format application/pdf
dc.format.extent 5 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Biomed central ca_ES
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons ca_ES
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es/ ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.subject.other VIH (Virus) ca_ES
dc.title Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1186/s12977-015-0206-0
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a WOS/JCR ca_ES
dc.indexacio Indexat a SCOPUS ca_ES

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