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Primary resistance to integrase strand-transfer inhibitors in Europe

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Casadellà, Maria
dc.contributor.author Van Ham, P.M.
dc.contributor.author Noguera-Julian, Marc
dc.contributor.author Van Kessel, A.
dc.contributor.author Pou, Christian
dc.contributor.author Hofstra, L.M.
dc.contributor.author Santos, José R.
dc.contributor.author Garcia, Federico
dc.contributor.author Struck, D.
dc.contributor.author Alexiev, I.
dc.contributor.author Bakken Kran, A.M.
dc.contributor.author Hoepelman, A.I.
dc.contributor.author Kostrikis, L.G.
dc.contributor.author Somogyi, S.
dc.contributor.author Liitsola, K.
dc.contributor.author Linka, M.
dc.contributor.author Nielsen, C.
dc.contributor.author Otelea, D.
dc.contributor.author Paraskevis, D.
dc.contributor.author Poljak, M.
dc.contributor.author Puchhammer-Stöckl, E.
dc.contributor.author Staneková, D.
dc.contributor.author Stanojevic, M.
dc.contributor.author Van Laethem, K.
dc.contributor.author Zidovec Lepej, S.
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Boucher, C.A.B.
dc.contributor.author Paredes, Roger
dc.contributor.author Wensing, A.M.J.
dc.date.accessioned 2015-11-16T12:01:52Z
dc.date.available 2015-11-16T12:01:52Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Casadellá, M., van Ham, P. M., Noguera-Julian, M., van Kessel, A., Pou, C., Hofstra, L. M., et al. (2015). Primary resistance to integrase strand-transfer inhibitors in europe. Journal of Antimicrobial Chemotherapy, 70(10), 2885-2888. ca_ES
dc.identifier.issn 1460-2091
dc.identifier.uri http://hdl.handle.net/10854/4357
dc.description.abstract Objectives: The objective of this study was to define the natural genotypic variation of the HIV-1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer inhibitor (InSTI) resistance. Methods: This was a multicentre, cross-sectional study within the European SPREAD HIV resistance surveillance programme. A representative set of 300 samples was selected from 1950 naive HIV-positive subjects newly diagnosed in 2006–07. The prevalence of InSTI resistance was evaluated using quality-controlled baseline population sequencing of integrase. Signature raltegravir, elvitegravir and dolutegravir resistance mutations were defined according to the IAS-USA 2014 list. In addition, all integrase substitutions relative to HXB2 were identified, including those with a Stanford HIVdb score ≥10 to at least one InSTI. To rule out circulation of minority InSTIresistant HIV, 65 samples were selected for 454 integrase sequencing. Results: For the population sequencing analysis, 278 samples were retrieved and successfully analysed. No signature resistance mutations to any of the InSTIswere detected. Eleven (4%) subjects hadmutations at resistance-associated positions with an HIVdb score ≥10. Of the 56 samples successfully analysed with 454 sequencing, no InSTI signature mutationsweredetected,whereas integrase substitutionswithanHIVdbscore≥10were found in8(14.3%) individuals. Conclusions:No signature InSTI-resistant variantswere circulating in Europe before the introduction of InSTIs. However, polymorphisms contributing to InSTI resistancewere not rare. As InSTI use becomes more widespread, continuous surveillance of primary InSTI resistance is warranted. These data will be key to modelling the kinetics of InSTI resistance transmission in Europe in the coming years. ca_ES
dc.format application/pdf
dc.format.extent 4 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Oxford University Press ca_ES
dc.rights Tots els drets reservats ca_ES
dc.rights (c) Oxford University Press
dc.subject.other Sida -- Tractament ca_ES
dc.title Primary resistance to integrase strand-transfer inhibitors in Europe ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1093/jac/dkv202
dc.rights.accessRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a WOS/JCR ca_ES
dc.indexacio Indexat a SCOPUS

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