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Evolutionary analyses of gene by environment variants associated to body shape in human populations

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author Cadenas Sevilla, Beatriz
dc.date.accessioned 2019-03-28T18:40:59Z
dc.date.available 2019-03-28T18:40:59Z
dc.date.created 2016-09-19
dc.date.issued 2016-09-19
dc.identifier.uri http://hdl.handle.net/10854/5755
dc.description Curs 2015-2016 es
dc.description.abstract Obesity and body fat distribution is a complex phenotype highly heritable. Genetic variants showing association with BMI, a measure of body size, or waist-to-hip ratio adjusted for BMI (WHRadjBMI ), a measure of body shape, have been identified through genome-wide association studies. It is well known that body size and shape change as people grow older and in addition there are substantial changes in both size and shape between men and women. These changes have been explained by means of several evolutionary hypotheses. However little is known about the evolution of the genetic variants underlying these phenotypes. In this study we have tested from the evolutionary perspective 12 SNPs associated with BMI with age-specific effects and 49 SNPs associated with WHRadjBMI with sex-specific effects identified and described by Winkler and Shungin. For that, we have analysed the genetic variation of those loci in human population and tested the presence of differential patterns of selective pressures in 940 unrelated individuals from 53 populations from the Human Genome Diversity Panel in a collaboration with Centre Etude Polymorphism Human (HGDP-CEPH). By applying different statistical methods, we detect gender associated selective pressures on genetic scores for WHRadjBMI differentially acting over populations , as well as limit evidence for age and BMI. es
dc.format application/pdf es
dc.format.extent 35 p. es
dc.language.iso eng es
dc.rights Tots els drets reservats es
dc.subject.other Genètica de poblacions humanes es
dc.subject.other Genètica humana es
dc.title Evolutionary analyses of gene by environment variants associated to body shape in human populations es
dc.type info:eu-repo/semantics/bachelorThesis es
dc.rights.accesRights info:eu-repo/semantics/closedAccess es

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