DSpace/Dipòsit Manakin

A pilot study on extracellular vesicles (EV)s and their small RNA (sRNA) expression pattern in Huntington's Disease progression

A pilot study on extracellular vesicles (EV)s and their small RNA (sRNA) expression pattern in Huntington's Disease progression
 
Redondo Guitarte, Ana Belén
15-09-2021

Text complet d'aquest document

Icon
Nom: trealu_a2021_redondo_ana belen_pilot_study.pdf
Mida: 1.685Mb
Format: PDF
Descripció: Accés restringit. Cliqueu la icona per sol·licitar una còpia.
Enllaç permanent: http://hdl.handle.net/10854/6926
 

Resum:

The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares Discriminant Analysis reveals transfer RNA-derived sRNAs (tRFs) as the biotype with stronger discrimination potential, both at ...»»»»
The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares Discriminant Analysis reveals transfer RNA-derived sRNAs (tRFs) as the biotype with stronger discrimination potential, both at premanifest and manifest stages. Thus, tRFs are targeted as potential biomarkers that would allow to discriminate early alterations in Huntington’s disease patients. This initial study shows promising results in a small set of samples that should be replicated in a larger cohort.^^^^

Tipus:

Treball fi de màster/Treball d'investigació

Drets:

Tots els drets reservats