A pilot study on extracellular vesicles (EV)s and  their small RNA (sRNA) expression pattern in  Huntington's Disease progression

Redondo Guitarte, Ana Belén

Inici
→
Docència
→
Treballs de l'alumnat
→
Treballs de Fi de Màster
→
Màster Universitari en Anàlisi de Dades Òmiques
→
Visualitza el document

dc.contributor	Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor	Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author	Redondo Guitarte, Ana Belén
dc.date.accessioned	2022-01-17T09:02:40Z
dc.date.available	2022-01-17T09:02:40Z
dc.date.created	2021-09-15
dc.date.issued	2021-09-15
dc.identifier.uri	http://hdl.handle.net/10854/6926
dc.description	Curs 2020-2021	es
dc.description.abstract	The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares Discriminant Analysis reveals transfer RNA-derived sRNAs (tRFs) as the biotype with stronger discrimination potential, both at premanifest and manifest stages. Thus, tRFs are targeted as potential biomarkers that would allow to discriminate early alterations in Huntington’s disease patients. This initial study shows promising results in a small set of samples that should be replicated in a larger cohort.	es
dc.format	application/pdf	es
dc.format.extent	25 p.	es
dc.language.iso	eng	es
dc.rights	Tots els drets reservats	es
dc.subject.other	Corea de Huntington (Malaltia)	es
dc.subject.other	RNA	es
dc.subject.other	Expressió gènica	es
dc.subject.other	Sistema nerviós -- Degeneració	es
dc.title	A pilot study on extracellular vesicles (EV)s and their small RNA (sRNA) expression pattern in Huntington's Disease progression	es
dc.type	info:eu-repo/semantics/masterThesis	es
dc.description.version	Director/a: Josep Maria Serrat
dc.description.version	Supervisor/a: Geòrgia Escaramís Babiano
dc.rights.accessRights	info:eu-repo/semantics/closedAccess	es