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Insights into the transcriptomic effects of olaparib response on a breast cancer preclinical model

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor.author Clavell Revelles, Pau
dc.date.accessioned 2023-03-08T16:19:36Z
dc.date.available 2023-03-08T16:19:36Z
dc.date.created 2022-09
dc.date.issued 2022-09
dc.identifier.uri http://hdl.handle.net/10854/7313
dc.description Curs 2021-2022 es
dc.description.abstract In the past decades, many breast cancer treatments have been approved. Although an effort has been done to identify sensitive patients to specific treatments, such as targeted therapies like poly(ADP-ribose) polymerases (PARP) inhibitors (PARPi), acquired resistances are commonly seen in the clinic. In order to characterize the transcriptional effects of the sensitivity and treatment of the PARP inhibitor olaparib, in this study, we have analysed bulk RNA-seq data of a cohort of patient-derived xenografts (PDX). After assessing the high inter-patient heterogeneity, we perform a differential expression analysis and a functional analysis that reveal an important role of interferons responses in olaparib effect. Finally, we investigate the tumour microenvironment by an immune cell-type deconvolution. es
dc.format application/pdf es
dc.format.extent 12 p. es
dc.language.iso eng es
dc.rights Tots els drets reservats es
dc.subject.other RNA es
dc.subject.other Càncer -- Aspectes genètics es
dc.title Insights into the transcriptomic effects of olaparib response on a breast cancer preclinical model es
dc.type info:eu-repo/semantics/masterThesis es
dc.description.version Tutores: Lara Nonell Mazelon, Violeta Serra i M.Luz Calle Rosingana
dc.rights.accessRights info:eu-repo/semantics/closedAccess es

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