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Browsing by Subject "Proteïnes -- Investigació"

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Codon frequency is modulated by proteic selection, resulting in a coding profile in Archaea and Yeast

Roginski, Paul Luc Maxime (08-2021)

Codons as fragments of the genetic code articulate both nucleotidic and proteic constraints. If codon usage bias is now admitted to be mainly influenced by GC content, codon frequencies in general may display a more ...
Development of E3-Independent protac molecules

Gonzàlez Artero, Alba (06-2020)

This project proposes to generate a new type of PROTAC molecules that can act independently of E3-ubiquitin ligases. The idea is to bind a target protein, which we want to degrade, directly to the proteasome. This is a ...
Genetic analysis of the anticoagulant proteins Antithrombin, Protein C and Protein S

Temprano Sagrera, Gerard (15-09-2020)

Cardiovascular diseases (CVDs) are the number one case of dead globally according to the World Health Organisation (WHO) ahead of cancer and respiratory diseases. Most of CVDs are caused by a combination of genetic, ...
HRAS physical feature analysis: Predicting protein activation through a random forest classifier

González García, Jorge (10-09-2023)

Over the past decade, increased computational capabilities have enabled us to address biological questions using data-driven methods, particularly where traditional techniques have been limiting. We hypothesize these ...
Initial exploration of vascular endothelial growth factor effect on fibroblasts in the context of wound healing

Navarro Páez, Francisco (06-2020)

Fibroblasts are key elements on the wound healing process, to close the wound they must migrate, migration is mediated by transmembrane proteins called integrins, especially by integrin α5β1. Anomalous integrin function ...
The impact and function of C-terminal degrons and protein misfolding in the degradation of truncated proteins

Sánchez Guixé, Mònica (15-09-2020)

Premature Termination Codons (PTCs) are mainly generated after nonsense and frameshift alterations. The Nonsense Mediated Decay (NMD) system detects and degrades mRNAs containing PTCs. However, the efficiency of this ...

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Browsing by Subject "Proteïnes -- Investigació"

Browsing by Subject "Proteïnes -- Investigació"

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