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Browsing Articles by Subject "Medicaments -- Assaigs clínics"

Now showing items 1-5 of 5

Binimetinib Encorafenib and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

Van Cutsem, Eric; Huijberts, Sanne; Grothey, Axel; Yaeger, Rona; Cuyle, Pieter-Jan; Elez, Elena; Fakih, Marwan; Montagut, Clara; Peeters, Marc; Yoshino, Takayuki; Kopetz, Scott; Tabernero, Josep (Lippincott Williams & Wilkins, 2019)

To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, three-arm, ...
Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial

Montagut, Clara; Argilés, Guillem; Ciardiello, Fortunato; Poulsen, Thomas T.; Dienstmann, Rodrigo; Kragh, Michael; Kopetz, Scott; Lindsted, Trine; Ding, Cliff; Vidal, Joana; Tabernero, Josep (American Medical Association, 2018)

IMPORTANCE Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory ...
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

Kopetz, Scott; Grothey, Axel; Yaeger, Rona; Van Cutsem, Eric; Desai, Jayesh; Yishino, Takayuki; Wasan, Harpreet; Ciardiello, Fortunato; Loupakis, Fotio; Tabernero, Josep (Massachusetts Medical Society, 2019)

Colorectal cancers with BRAF mutations have an aggressive natural history and are often resistant to therapy. A treatment regimen that combined BRAF inhibition, MET inhibition, and blocking of EGFR signaling resulted in a ...
Multicenter Phase I Study of Erdafitinib (JNJ-42756493) Oral Pan-Fibroblast Growth Factor Receptor Inhibitor in Patients with Advanced or Refractory Solid Tumors

Bahleda, Rastislav; Italiano, Antoine; Hierro, Cinta; Mita, Alain; Cervantes, Andrés; Chan, Nancy; Awad, Mark; Moreno, Víctor; Tabernero, Josep (American Association Cancer Research, 2019)

Purpose: Here, we report results of the first phase I study of erdafitinib, a potent, oral pan-FGFR inhibitor. Patients and Methods: Patients age >= 18 years with advanced solid tumors for which standard antineoplastic ...
Phase II Study of the Dual EGFR/HER3 Inhibitor Duligotuzumab (MEHD7945A) versus Cetuximab in Combination with FOLFIRI in Second-Line RAS Wild-Type Metastatic Colorectal Cancer

Hill, Andrew G.; Findlay, Michael P.; Burge, Matthew E.; Jackson, Christopher; Garcia Alfonso, Pilar; Samuel, Leslie; Ganju, Vinod; Karthaus, Meinolf; Amatu, Alessio; Tabernero, Josep (American Association Cancer Research, 2018)

Purpose: Duligotuzumab is a dual-action antibody directed against EGFR and HER3. Experimental Design: Metastatic colorectal cancer (mCRC) patients with KRAS ex2 wild-type received duligotuzumab or cetuximab and FOLFIRI ...

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