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Association between polymorphic inversions and miRNA in cancer data

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author Ramírez Priego, Patricia
dc.date.accessioned 2019-02-07T17:06:16Z
dc.date.available 2019-02-07T17:06:16Z
dc.date.created 2016-09
dc.date.issued 2016-09
dc.identifier.uri http://hdl.handle.net/10854/5677
dc.description Curs 2015-2016
dc.description.abstract Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently developed computational methods have enabled to discover new human inversion polymorphisms and their association with complex diseases. To overcome this lack of knowledge, we aimed to investigate the effect of four well characterized inversions (8p23, 15q24.2, 16p11.2 and 17q23.31) on miRNA expression in cancer samples. We perform an association analysis between inversion and miRNA expression and Gene Ontology enrichment analysis using different R packages. Our preliminary findings show that there are an association between miRNA expression and cancer, and that it affects important pathways related to cancer. es
dc.format application/pdf es
dc.format.extent 54 p. es
dc.language.iso eng es
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons es
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/es/ es
dc.subject.other Bioinformàtica es
dc.subject.other Càncer es
dc.subject.other ADN es
dc.title Association between polymorphic inversions and miRNA in cancer data es
dc.type info:eu-repo/semantics/masterThesis es
dc.description.version Director/a: Juan Ramón González Co-director/a: Josep Maria Jurado
dc.description.version Supervisor:
dc.rights.accesRights info:eu-repo/semantics/openAccess es

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