Registre simple
dc.contributor |
Universitat de Vic - Universitat Central de Catalunya. Facultat de Medicina |
|
dc.contributor |
Universitat de Girona |
|
dc.contributor |
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV |
|
dc.contributor.author |
Martinez Moreno, Rebecca |
|
dc.contributor.author |
Carreras, David |
|
dc.contributor.author |
Aran, Begoña |
|
dc.contributor.author |
Kuebler, Bernd |
|
dc.contributor.author |
Sarquella Brugada, Georgia |
|
dc.contributor.author |
Brugada, Ramon |
|
dc.contributor.author |
Pérez, Guillermo J. |
|
dc.contributor.author |
Scornik, Fabiana S. |
|
dc.contributor.author |
Selga, Elisabet |
|
dc.date.accessioned |
2024-07-09T08:56:55Z |
|
dc.date.available |
2024-07-09T08:56:55Z |
|
dc.date.created |
2022 |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Martínez-Moreno, R., Pérez-Serra, A., Carreras, D., Aran, B., Kuebler, B., Brugada, R., Selga, E. (2022). Generation of an induced pluripotent stem cell line from a healthy caucasian male. Stem Cell Research, 60(102717). https://doi.org/10.1016/j.scr.2022.102717 |
es |
dc.identifier.issn |
1873-5061 |
|
dc.identifier.uri |
http://hdl.handle.net/10854/8078 |
|
dc.description.abstract |
Patient-derived induced pluripotent stem cells (iPSC) are a valuable approach to model cardiovascular diseases. We nucleofected non-integrating episomal vectors in
skin fibroblasts of three family members carrying a single nucleotide variant (SNV) in SCN5A, which encodes the cardiac-type sodium channel, and of a related
healthy control. The SNV SCN5A_c.4573G > A had been previously identified in a Brugada Syndrome patient. The resulting iPS cell lines differentiate into cells of the
3 germ layers, display normal karyotypes and express pluripotency surface markers and genes. Thus, they are a reliable source to study the effect of the identified
mutation in a physiologically relevant environment. |
es |
dc.format |
application/pdf |
es |
dc.format.extent |
5 p. |
es |
dc.language.iso |
eng |
es |
dc.publisher |
Elsevier |
es |
dc.rights |
Aquest document està subjecte a aquesta llicència Creative Commons |
es |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ca |
es |
dc.subject.other |
Sistema cardiovascular -- Malalties |
es |
dc.subject.other |
Cor -- Malalties |
es |
dc.title |
Generation of four induced pluripotent stem cell lines from a family harboring a single nucleotide variant in SCN5A |
es |
dc.type |
info:eu-repo/semantics/article |
es |
dc.identifier.doi |
https://doi.org/10.1016/j.scr.2022.102717 |
|
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
es |
dc.type.version |
info:eu-repo/publishedVersion |
es |
dc.indexacio |
Indexat a WOS/JCR |
es |
dc.indexacio |
Indexat a SCOPUS |
es |
Text complet d'aquest document
Registre simple
Aquest document està subjecte a aquesta llicència Creative Commons