DSpace Repository

High Prevalence of Signs of Renal Damage Despite Normal Renal Function in a Cohort of HIV-Infected Patients: Evaluation of Associated Factors

Show simple item record

dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Bonjoch, Anna
dc.contributor.author Juega, J.
dc.contributor.author Puig, Jordi
dc.contributor.author Pérez Alvarez, Núria
dc.contributor.author Aiestarán, A.
dc.contributor.author Echeverria, Patricia
dc.contributor.author Pérez, V.
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Romero, R.
dc.contributor.author Bonet, J.
dc.contributor.author Negredo, Eugenia
dc.date.accessioned 2014-10-30T13:40:00Z
dc.date.available 2014-10-30T13:40:00Z
dc.date.created 2014
dc.date.issued 2014
dc.identifier.citation Bonjoch, A., Juega, J., Puig, J., Perez-Alvarez, N., Aiestaran, A., Echeverria, P., et al. (2014). High prevalence of signs of renal damage despite normal renal function in a cohort of HIV-infected patients: Evaluation of associated factors. AIDS Patient Care and STDs, 28(10), 524-529. ca_ES
dc.identifier.issn 1087-2914
dc.identifier.uri http://hdl.handle.net/10854/3466
dc.description.abstract Renal disorders are an emerging problem in HIV-infected patients. We performed a cross-sectional study of the first 1000 HIV-infected patients attended at our HIV unit who agreed to participate. We determined the frequency of renal alterations and its related risk factors. Summary statistics and logistic regression were applied. The study sample comprised 970 patients with complete data. Most were white (94%) and men (76%). Median (IQR) age was 48 (42–53) years. Hypertension was diagnosed in 19%, dyslipidemia in 27%, and diabetes mellitus in 3%. According to the Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation, 29 patients (3%) had an eGFR < 60 ml/min/1.73m2; 18 of them (62%) presented altered albumin/creatinine and protein/creatinine (UPC or UAC) ratios. Of the patients with eGFR> 60mL/min, it was present in 293 (30%), 38 of whom (7.1%) had UPC> 300mg/g. Increased risk of renal abnormalities was correlated with hypertension (OR, 1.821 [95%CI, 1.292;2.564]; p = 0.001), age (OR, 1.015 [95%CI, 1.001;1.030], per one year; p = 0.040), and use of tenofovir disoproxil fumarate (TDF) plus protease inhibitor (PI), (OR, 1.401 [95%CI, 1.078;1.821]; p = 0.012). Current CD4 cell count was a protective factor (OR, 0.9995 [95%CI, 0.9991;0.9999], per one cell; p = 0.035). A considerable proportion of patients presented altered UPC or UAC ratios, despite having an eGFR > 60mL/min. CD4 cell count was a protective factor; age, hypertension, and use of TDF plus PIs were risk factors for renal abnormalities. Based on our results, screen of renal abnormalities should be considered in all HIV-infected patients to detect these alterations early. ca_ES
dc.format application/pdf
dc.format.extent 6 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Mary Ann Liebert ca_ES
dc.rights This is a copy of an article published in the [AIDS PATIENT CARE AND STDS] © [2014] [copyright Mary Ann Liebert, Inc.]; [AIDS Patient Care and STDs] is available online at: http://online.liebertpub.com.
dc.rights Tots els drets reservats ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title High Prevalence of Signs of Renal Damage Despite Normal Renal Function in a Cohort of HIV-Infected Patients: Evaluation of Associated Factors ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1089/apc.2014.0172
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES
dc.titol.revista Indexat a WOS/JCR
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a CARHUS+
dc.indexacio Indexat a SCOPUS ca_ES

Files in this item

Show simple item record

Search RIUVic

Advanced Search