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A Post-Partum Single-Dose TDF/FTC Tail Does Not Prevent the Selection of NNRTI Resistance in Women Receiving Pre-Partum ZDV and Intrapartum Single-Dose Nevirapine to Prevent Mother-to-Child HIV-1 Transmission

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Reshmi, Samuel
dc.contributor.author Paredes, Roger
dc.contributor.author Parboosing, Raveen
dc.contributor.author Moodley, Pravi
dc.contributor.author Singh, Lavanya
dc.contributor.author Naidoo, Anneta
dc.contributor.author Gordon, M.
dc.date.accessioned 2015-09-28T11:20:20Z
dc.date.available 2015-09-28T11:20:20Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Samuel, R., Paredes, R., Parboosing, R., Moodley, P., Singh, L., Naidoo, A., et al. (2015). A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission. Journal of Medical Virology, 87(10), 1662-1667. ca_ES
dc.identifier.issn 0146-6615
dc.identifier.uri http://hdl.handle.net/10854/4227
dc.description.abstract Although the rates of vertical transmission of HIV in the developing world have improved to around 3% in countries like South Africa, resistance to antiretrovirals (ARV) used in Prevention of Mother-to-Child transmission (pMTCT) strategies may thwart such outcomes and affect the efficacy of future ARV regimens in mothers and children. This study conducted in Durban, South Africa, between 2010 and 2013 found a high rate of nevirapine (NVP) resistance among women receiving Zidovudine (AZT) from 14 weeks gestation, single dose nevirapine (sd NVP) at the onset of labor and a single dose of coformulated Tenofovir/Emtricitabine (TDF/FTC) postpartum. Using Sanger sequencing, high and intermediate levels of nevirapine (NVP) resistance were detected in 15/44 (34%) and in 1/44 (2%) of women tested, respectively. Most subjects selected the K103N mutation (22% (10/45) of all patients and 66% (10/15) of those with high-level NVP resistance). Such rate of NVP resistance is comparable to studies where only sd NVP was used. In conclusion, a post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum sd NVP to prevent mother-tochild HIV-1 transmission. en
dc.format application/pdf
dc.format.extent 6 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Wiley ca_ES
dc.rights Tots els drets reservats ca_ES
dc.rights (c) Blackwell Wiley [The definitive version is available at www3.interscience.wiley.com]
dc.subject.other Sida -- Tractament ca_ES
dc.title A Post-Partum Single-Dose TDF/FTC Tail Does Not Prevent the Selection of NNRTI Resistance in Women Receiving Pre-Partum ZDV and Intrapartum Single-Dose Nevirapine to Prevent Mother-to-Child HIV-1 Transmission en
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1002/jmv.24220
dc.rights.accesRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a SCOPUS ca_ES

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