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FARMS: A New Algorithm for Variable Selection

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Pérez-Alvarez, Susana
dc.contributor.author Gómez, Guadalupe
dc.contributor.author Brander, Christian
dc.date.accessioned 2015-11-02T09:26:07Z
dc.date.available 2015-11-02T09:26:07Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Perez-Alvarez, S., Gómez, G., & Brander, C. (2015). FARMS: A new algorithm for variable selection. BioMed Research International, 2015 ca_ES
dc.identifier.uri http://hdl.handle.net/10854/4330
dc.description.abstract Large datasets including an extensive number of covariates are generated these days in many different situations, for instance, in detailed genetic studies of outbreed human populations or in complex analyses of immune responses to different infections. Aiming at informing clinical interventions or vaccine design, methods for variable selection identifying those variables with the optimal prediction performance for a specific outcome are crucial. However, testing for all potential subsets of variables is not feasible and alternatives to existing methods are needed.Here,we describe a newmethod to handle such complex datasets, referred to as FARMS, that combines forward and all subsets regression formodel selection.We apply FARMS to a host genetic and immunological dataset of over 800 individuals from Lima (Peru) and Durban (South Africa) who were HIV infected and tested for antiviral immune responses. This dataset includes more than 500 explanatory variables: around 400 variables with information on HIV immune reactivity and around 100 individual genetic characteristics.We have implemented FARMS in R statistical language and we showed that FARMS is fast and outcompetes other comparable commonly used approaches, thus providing a new tool for the thorough analysis of complex datasets without the need for massive computational infrastructure. ca_ES
dc.format application/pdf
dc.format.extent 12 p. ca_ES
dc.language.iso eng ca_ES
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons ca_ES
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es/ ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title FARMS: A New Algorithm for Variable Selection ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1155/2015/319797
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a SCOPUS ca_ES

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